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首页> 外文期刊>Critical reviews in microbiology >Drug resistance to Mycobacterium tuberculosis: From the traditional Chinese view to modern systems biology
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Drug resistance to Mycobacterium tuberculosis: From the traditional Chinese view to modern systems biology

机译：对结核分枝杆菌的耐药性：从中国传统观点到现代系统生物学

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摘要

The pathogen, Mycobacterium tuberculosis (M. tuberculosis) is a well-evolved, organized pathogen that has developed drug resistance, specifically multidrug resistance (MDR) and extensive drug resistance (XDR). This review primarily summarizes the mechanisms of drug resistance by M. tuberculosis according to the traditional Chinese view. The traditional Chinese view of drug resistance includes: the physical barrier of the cell wall; mutations relating to current anti-TB agents; drug efflux pumps; and drug stress, including the SOS response systems, the mismatch repair systems and the toxin-antitoxin systems. In addition, this review addresses the integrated systems biology of genomics, transcriptomics, proteomics, metabolomics and interactomics. Development of the various levels of systems biology has enabled determination of the anatomy of bacteria. Finally, the current review proposes that further investigation regarding the population of individuals with a high drug metabolic speed is vital to further understand drug resistance in M. tuberculosis.
机译：病原体结核分枝杆菌（结核分枝杆菌）是一种发展良好的，有组织的病原体，已发展出耐药性，特别是多药耐药性（MDR）和广泛耐药性（XDR）。这篇综述主要根据中国传统观点总结了结核分枝杆菌的耐药机制。中国传统的抗药性观点包括：细胞壁的物理屏障;与当前抗结核病药物有关的突变;药物外排泵;和药物压力，包括SOS反应系统，错配修复系统和毒素-抗毒素系统。此外，本综述涉及基因组学，转录组学，蛋白质组学，代谢组学和相互作用组学的集成系统生物学。各种水平系统生物学的发展使得能够确定细菌的解剖结构。最后，本综述提出，关于药物代谢速度快的个体的进一步研究对于进一步了解结核分枝杆菌的耐药性至关重要。

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