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首页> 外文期刊>Critical reviews in oncogenesis >An immune regulatory cytokine receptor and glioblastoma multiforme: an unexpected link.
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An immune regulatory cytokine receptor and glioblastoma multiforme: an unexpected link.

机译：免疫调节细胞因子受体和胶质母细胞瘤的多种形式：一个意想不到的联系。

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摘要

Human high-grade gliomas (HGG) are one of the most devastating human malignancies. They are rapidly progressing heterogenous tumors for which no curable treatment is available. Although these tumors are believed to be of glial cell origin, known tumor-specific markers do not characterize them. The specific environmental conditions that cause or promote the development of HGG are not known. The pathomechanism of HGG is yet to be revealed, although more specific genetic alterations are assigned to HGG. Recently, we have found that HGG overexpress a receptor for an immune regulatory cytokine, interleukin-13 (IL-13). In fact, it appears that all patients with glioblastoma multiforme may possess this receptor. IL-13 is an antiinflammatory cytokine with many overlapping functions to its homologue, IL-4. There is a high degree of specificity of the overexpression of the IL-13 receptor in HGG. This receptor is not only quantitatively but also qualitatively different from the only known functional signaling receptor for IL-13 of normal tissue. It is not shared with IL-4. The more restrictive receptor for IL-13 thus may represent a new factor specific for a disease as heterogenous as HGG.
机译：人类高级神经胶质瘤（HGG）是最严重的人类恶性肿瘤之一。他们正在迅速发展为无法治愈的异质性肿瘤。尽管这些肿瘤被认为是神经胶质细胞起源的，但是已知的肿瘤特异性标记物却不能作为它们的特征。导致或促进HGG发育的特定环境条件尚不清楚。尽管更具体的遗传改变被分配给HGG，HGG的致病机理尚未被揭示。最近，我们发现HGG过表达免疫调节细胞因子白介素13（IL-13）的受体。实际上，似乎所有患有多形性胶质母细胞瘤的患者都可能具有该受体。 IL-13是一种抗炎细胞因子，与其同系物IL-4具有许多重叠功能。 HGG中IL-13受体的过度表达具有高度特异性。该受体不仅在数量上而且在质量上与正常组织的IL-13唯一已知的功能性信号受体不同。它不与IL-4共享。因此，IL-13的限制性更强的受体可能代表了对像HGG这样异质性疾病具有特异性的新因子。

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