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Increased Eotaxin in Tears of Patients Wearing Contact Lenses.

机译：戴隐形眼镜的患者眼泪中的趋化因子增加。

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PURPOSE:: Giant papillary conjunctivitis in patients wearing contact lenses occurs after intolerance and/or allergy to contact lenses. Eotaxin is a CC chemokine with a potent and specific chemotactic effect for eosinophils, which are involved in allergies. The purpose of this study is to measure the eotaxin levels in tears of patients wearing contact lenses and in normal subjects. Eotaxin levels were also correlated with the grade of giant papillary conjunctivitis. METHODS:: Around 10 渭L of tears were collected with glass capillaries in 16 patients wearing contact lenses and in 10 normal volunteers. Giant papillary conjunctivitis was graded from 0 to 4 by reference to standard slit-lamp photographs of the superior tarsal conjunctiva. Eotaxin concentration in tears was measured by ELISA using mouse anti-human eotaxin monoclonal antibodies. For the statistical analysis of the results, the paired Wilcoxon/Kruskal-Wallis test was used. RESULTS:: The mean concentration of eotaxin was 2698 +/- 233 (SEM) pg/mL in patients wearing contact lenses and 1498 +/- 139 pg/mL in normal subjects. The difference was statistically significant (P = 0.0004). The mean score of papilla grade was 1.75 +/- 0.19 in patients wearing contact lenses and 0.2 +/- 0.13 in normal subjects (P < 0.0001). Papilla grade could be correlated to the eotaxin level in tears (R = 0.6562 and P < 0.0001). CONCLUSION:: An increase of eotaxin levels in tears was measured in patients wearing contact lenses. Eotaxin levels correlated with the severity of giant papillary conjunctivitis. These data suggest that eotaxin could play a role in papilla formation.
机译：目的：戴隐形眼镜的患者发生巨乳头结膜炎是在对隐形眼镜不耐受和/或过敏后发生的。嗜酸性粒细胞趋化因子是一种CC趋化因子，对参与过敏的嗜酸性粒细胞具有有效的特异性趋化作用。这项研究的目的是测量戴隐形眼镜的患者和正常受试者的眼泪中的趋化因子水平。趋化因子水平也与巨乳头结膜炎的程度相关。方法：在16名戴隐形眼镜的患者和10名正常志愿者中，用玻璃毛细管收集了约10μL的眼泪。参照上睑结膜的标准裂隙灯照片，将巨乳头结膜炎的评分从0分为4。使用小鼠抗人嗜酸性粒细胞趋化因子单克隆抗体通过ELISA测定眼泪中嗜酸性粒细胞趋化因子的浓度。对于结果的统计分析，使用了配对的Wilcoxon / Kruskal-Wallis检验。结果：戴隐形眼镜的患者中嗜酸性粒细胞趋化因子的平均浓度为2698 +/- 233（SEM）pg / mL，而正常受试者中的为1498 +/- 139 pg / mL。差异具有统计学意义（P = 0.0004）。戴隐形眼镜的患者的乳头等级平均得分为1.75 +/- 0.19，而正常受试者的平均得分为0.2 +/- 0.13（P <0.0001）。乳头等级可能与眼泪中的趋化因子水平相关（R = 0.6562，P <0.0001）。结论：戴隐形眼镜的患者眼泪中嗜酸性粒细胞趋化因子水平升高。趋化因子水平与巨乳头结膜炎的严重程度相关。这些数据表明嗜酸细胞活化趋化因子可能在乳头形成中起作用。

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