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首页> 外文期刊>Biochemical and Biophysical Research Communications >Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer.
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Polymorphisms of MLH1 in benign prostatic hyperplasia and sporadic prostate cancer.

机译：MLH1在前列腺增生和散发性前列腺癌中的多态性。

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摘要

Mismatch repair is one of several DNA repair pathways of which defects may lead to cancer. We hypothesize that polymorphisms of the MLH1 gene can be a risk factor for benign prostatic hyperplasia (BPH) and prostate cancer. The genetic distribution of MLH1 polymorphisms that lead to amino acid changes at codons 132, 219, 384, and 723 were analyzed in BPH and sporadic prostate cancer patients, and compared to healthy controls from an Asian population. These experiments demonstrate a protective role for the codon 384 variant allele against prostate cancer (P=0.031) but not BPH when compared to normal controls and furthermore, an inverse association was observed with stage (P=0.074) and grade (P=0.056) of cancer. This is the first report that demonstrates a protective effect for the race-related MLH1 polymorphism at codon 384 against prostate cancer and these results are important in understanding their role in this disease.
机译：错配修复是几种DNA修复途径之一，其缺陷可能导致癌症。我们假设MLH1基因的多态性可能是良性前列腺增生（BPH）和前列腺癌的危险因素。在BPH和散发性前列腺癌患者中分析了导致132、219、384和723位密码子氨基酸改变的MLH1多态性的遗传分布，并将其与亚洲人群的健康对照进行了比较。这些实验证明，与正常对照相比，密码子384变异等位基因对前列腺癌具有保护作用（P = 0.031），但对BPH没有保护作用，此外，观察到与阶段（P = 0.074）和等级（P = 0.056）呈负相关癌症。这是第一份证明对种族相关的MLH1多态性在384位密码子上具有针对前列腺癌的保护作用的报告，这些结果对于理解其在该疾病中的作用非常重要。

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