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首页> 外文期刊>Critical Reviews in Biomedical Engineering >Laser non-contact drug delivery methods: Mathematical and experimental substantiation [Review]
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Laser non-contact drug delivery methods: Mathematical and experimental substantiation [Review]

机译：激光非接触式药物递送方法：数学和实验依据[综述]

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This article outlines the existing methods for parenteral drug delivery. It also presents novel alternative methods based on laser technologies, namely laser impregnation and laser injection. A mathematical model is constructed to calculate laser impregnator's technical parameters, such as the energy density of laser radiation, pulse duration, and pulse repetition frequency. This model also makes it possible to estimate the increase in the diffusion rate of drug preparations when they are impregnated through multilayer structures, such as the skin. Moreover, this article presents experimental results on Er:YAG laser injection of various drug media, such as spirit solutions, aqueous solutions, and ointments. These preparations were injected into gelatinous gel and autopsy skin samples. Possible clinical application is considered for these laser transcutaneous drug delivery methods. [References: 31]
机译：本文概述了肠胃外给药的现有方法。它还提出了基于激光技术的新颖替代方法，即激光浸渍和激光注入。构建数学模型以计算激光浸渍器的技术参数，例如激光辐射的能量密度，脉冲持续时间和脉冲重复频率。当药物制剂通过多层结构（如皮肤）浸渍时，该模型还可以估计药物制剂的扩散速率增加。此外，本文还介绍了用Er：YAG激光注射各种药物介质（如酒精溶液，水溶液和软膏）的实验结果。将这些制剂注射到凝胶状凝胶和尸检皮肤样品中。这些激光经皮给药方法考虑了可能的临床应用。 [参考：31]

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