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首页> 外文期刊>Physical review, E. Statistical physics, plasmas, fluids, and related interdisciplinary topics >Improved energy model for membrane electroporation in biological cells subjected to electrical pulses - art. no. 041920
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Improved energy model for membrane electroporation in biological cells subjected to electrical pulses - art. no. 041920

机译：经受电脉冲的生物细胞中膜电穿孔的改进能量模型-艺术。没有。 041920

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A self-consistent model analysis of electroporation in biological cells has been carried out based on an improved energy model. The simple energy model used in the literature is somewhat incorrect and unphysical for a variety of reasons. Our model for the pore formation energy E(r) includes a dependence on pore population and density. It also allows for variable surface tension, incorporates the effects of finite conductivity on the electrostatic correction term, and is dynamic in nature. Self-consistent calculations, based on a coupled scheme involving the Smoluchowski equation and the improved energy model, are presented. It is shown that E(r) becomes self-adjusting with variations in its magnitude and profile, in response to pore population, and inhibits uncontrolled pore growth and expansion. This theory can be augmented to include pore-pore interactions to move beyond the independent pore picture. [References: 43]
机译：基于改进的能量模型，进行了生物细胞中电穿孔的自洽模型分析。由于多种原因，文献中使用的简单能量模型在某种程度上是不正确的和不自然的。我们的孔隙形成能E（r）模型包括对孔隙数量和密度的依赖性。它还允许变化的表面张力，在静电校正项中包含有限电导率的影响，并且本质上是动态的。提出了基于包含Smoluchowski方程和改进的能量模型的耦合方案的自洽计算。结果表明，E（r）随孔隙数量的变化而随着其大小和轮廓的变化而进行自我调节，并抑制了不受控制的孔隙生长和膨胀。可以扩充该理论以包括孔-孔相互作用以超越独立的孔图。 [参考：43]

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