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首页> 外文期刊>Cornea >Corneal endothelial cell density and morphology after acute hydrops in keratoconus.
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Corneal endothelial cell density and morphology after acute hydrops in keratoconus.

机译：圆锥角膜急性积水后角膜内皮细胞密度和形态。

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PURPOSE: To compare central corneal endothelium cell density and morphology in eyes with keratoconus and unilateral resolved hydrops with the unaffected fellow eye. METHODS: Bilateral confocal microscopy was performed 3 months after resolution of acute unilateral hydrops in patients with keratoconus who presented to the King Khaled Eye Specialist Hospital between February 1, 2004, and November 31, 2005. RESULTS: Twenty-six patients (19 men and 7 women) with a mean age of 22 years (range, 11-36 years) were enrolled in the study. A history of ocular allergy or rigid gas-permeable hard contact lens wear was present in 14 and 12 patients, respectively. The mean interval to resolution of hydrops was 12 weeks (range, 9-14 weeks), after which neovascularization was present in 8 eyes. The mean endothelial cell density in affected and unaffected eyes was virtually identical (2759 vs. 2788 cells/mm2, respectively; P = 0.82), although 5 (19.2%) affected eyes did have endothelial cell density that was >15% less than that of the unaffected fellow eye. Compared with unaffected eyes, there was a mean increase polymegathism in affected eyes from 33% to 35% and a mean decrease in hexagonality from 60% to 55%, but these differences were not statistically significant (P = 0.11 and 0.06, respectively). CONCLUSIONS: Decreased endothelial cell density is uncommon after resolution of acute hydrops, although morphologic changes may be present in a majority of cases.
机译：目的：比较圆锥角膜和单侧分辨性积液的眼睛与未患病同眼的中央角膜内皮细胞密度和形态。方法：在2004年2月1日至2005年11月31日之间向Khaled眼科专科医院就诊的圆锥角膜患者急性单侧积水消退后3个月进行了双侧共聚焦显微镜检查。结果：26例患者（19例男性该研究纳入了平均年龄为22岁（11-36岁）的7名女性。分别有14位和12位患者存在眼部过敏或硬质透气性硬性隐形眼镜的佩戴史。解决积水的平均间隔为12周（9-14周），此后8眼出现新血管形成。受影响和未受影响的眼睛的平均内皮细胞密度实际上是相同的（分别为2759 vs. 2788细胞/ mm2; P = 0.82），尽管有5只（19.2％）受影响的眼睛的内皮细胞密度确实比其低15％不受影响的同伴的眼睛。与未受影响的眼睛相比，患病眼的多角体病平均增加了33％至35％，六角形平均减少了60％至55％，但这些差异无统计学意义（分别为P = 0.11和0.06）。结论：急性水肿消退后，内皮细胞密度降低并不常见，尽管大多数情况下可能会出现形态学改变。

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