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Keratoconus associated with other corneal dystrophies.

机译：圆锥角膜与其他角膜营养不良有关。

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OBJECTIVE: To report the concomitant presentation of keratoconus and corneal dystrophies at Wills Eye Hospital for the 10-year period from January 1, 1997, to December 31, 2006. METHODS: Patients with concomitant keratoconus and corneal dystrophies were identified using a computer database. Complete ophthalmologic examination, keratometry, pachymetry, and computerized videokeratography were performed in all patients. When present, cornea guttata were confirmed by clinical examination and specular microscopy. Histopathologic examination with special stains of excised corneal buttons was performed. RESULTS: Fifty-one patients manifested typical signs and topographic evidence of keratoconus associated with another corneal dystrophy. Fuchs dystrophy was the most common association accounting for 27 cases (52.9%), followed by anterior basement membrane dystrophy with 13 cases (25.5%) and posterior polymorphous dystrophy with 7 cases (13.8%). A bilateral combination of Fuchs dystrophy and anterior basement membrane dystrophy with keratoconus was seen in 3 cases (5.8%). Finally, there was 1 bilateral case (2%) of granular dystrophy. Histopathologic studies in cases that underwent penetrating keratoplasty confirmed the clinical diagnoses. CONCLUSION: To our knowledge, this is the largest report of such a concurrence in the English literature and could lead to further studies on the possible pathophysiologic or genetic links between these entities, although a chance association cannot be excluded.
机译：目的：报告威尔斯眼科医院在1997年1月1日至2006年12月31日的10年中同时出现圆锥角膜和角膜营养不良的情况。方法：使用计算机数据库鉴定患有圆锥角膜和角膜营养不良的患者。所有患者均进行了完整的眼科检查，角膜曲率测定，厚度测定和计算机视频角膜造影。当存在角膜胶质时，可通过临床检查和镜面显微镜检查确认。用切除的角膜纽扣的特殊染色进行组织病理学检查。结果：51例患者表现出圆锥角膜与另一种角膜营养不良有关的典型体征和地形学证据。福克斯营养不良最常见，占27例（52.9％），其次是前基底膜营养不良13例（25.5％）和后部多形营养不良7例（13.8％）。观察到Fuchs营养不良和前基底膜营养不良合并圆锥角膜的双侧合并症3例（5.8％）。最终，有1例双侧病例（2％）出现颗粒性营养不良。进行穿透性角膜移植术的病例的组织病理学研究证实了临床诊断。结论：据我们所知，这是英国文献中有关此类同意的最大报道，尽管不能排除机会关联，但可能导致对这些实体之间可能的病理生理或遗传联系的进一步研究。

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