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Voriconazole-Loaded Nanostructured Lipid Carriers for Ocular Drug Delivery

机译：伏立康唑负载的纳米结构脂质载体用于眼部药物递送

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Purpose:To design and evaluate the potential of a topical delivery system for ocular administration of voriconazole, based on cationic nanostructured lipid carriers (NLCs).Methods:NLC dispersions composed of glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, and cetylpyridinium chloride were obtained and characterized. Ex vivo permeations experiments were performed to evaluate their drug delivery potential.Results:NLCs presented a mean diameter of 250.2 03.1 nm, narrow polydispersity index (0.288 +/- 0.03), positive zeta potential (31.22 +/- 3.8 mV), and over 75% encapsulation efficiency. Ex vivo ocular experiments proved that NLCs were able to deliver therapeutically relevant drug amounts to the cornea after only 30 minutes (13.88 +/- 0.24 g/cm(2)).Conclusions:The formulation was nonexpensive, easy to prepare, and composed of well-tolerated and accepted excipients. Further in vivo experiments are necessary to confirm the improved performance and tolerability of the formulation.
机译：目的：设计和评估基于阳离子纳米结构脂质载体（NLCs）的伏立康唑眼部给药局部给药系统的方法。获得并表征了氯化物。结果：NLCs的平均直径为250.2 03.1 nm，窄的多分散指数（0.288 +/- 0.03），ζ电势为正（31.22 +/- 3.8 mV），且超过75％的封装效率。离体眼睛实验证明，仅30分钟（13.88 +/- 0.24 g / cm（2）），NLC就能将治疗相关的药物释放到角膜上。结论：该制剂价格便宜，易于制备且由以下成分组成耐受性良好且可接受的赋形剂。需要进一步的体内实验来确认制剂的改善的性能和耐受性。

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