• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cornea >The Fixed Combination of Fortified Vancomycin and Amikacin Ophthalmic Solution-VA Solution: In Vitro Study of the Potency and Stability.
【24h】

The Fixed Combination of Fortified Vancomycin and Amikacin Ophthalmic Solution-VA Solution: In Vitro Study of the Potency and Stability.

机译：加强型万古霉素和丁胺卡那霉素滴眼液-VA溶液的固定组合：效力和稳定性的体外研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE:: We compared the in vitro potency and stability of a fixed combination of vancomycin and amikacin solution (VA solution) with amikacin or vancomycin solution. METHODS:: Solutions of 2% amikacin (20 mg/mL) and of 5% vancomycin (50 mg/mL) and VA solution (each 1 mL contained 20 mg of amikacin and 50 mg of vancomycin) were prepared from parenteral antibiotics by reconstituting them with sterile injection water and refrigerated (4 degrees C) in the dark. Triplicate 5-mL portions of each solution were tested before storage and 7 and 14 days after preparation for potency of antimicrobial activity by the disk diffusion method and for stability. RESULTS:: There were no significant differences in the diameter of zones of inhibition of VA solution compared with amikacin or vancomycin solution within a 2-week period. Visual inspection revealed that all solutions remained clear, colorless, and particle-free at 4 degrees C throughout the study period. For osmolarity, the VA solution was much higher than that of either amikacin or vancomycin solution at all tested times and more near the well-tolerated range of human eyes. There were no significant differences at days 0, 7, or 14 for either vancomycin, amikacin, or VA solution. For pH, the VA solution was higher than that of vancomycin solution (nearly equal to that of amikacin solution) at each time and more near the level of normal tear film. The pH did not differ significantly for either vancomycin, amikacin, or VA solution at all tested times. CONCLUSIONS:: The vancomycin and amikacin ophthalmic solutions can be mixed together with the same potency and stable physical properties. It may be useful in the treatment of bacterial keratitis pending clinical trials to determine its effectiveness and safety.
机译：目的：:我们比较了万古霉素和阿米卡星溶液（VA溶液）与阿米卡星或万古霉素溶液固定组合的体外效价和稳定性。方法：由肠胃外抗生素经复溶制备2％阿米卡星（20 mg / mL）和5％万古霉素（50 mg / mL）和VA溶液（每1 mL含有20 mg阿米卡星和50 mg万古霉素）将它们用无菌注射用水冲洗，并在黑暗中冷藏（4摄氏度）。在储存前以及制备后的7和14天，通过圆盘扩散法测试每种溶液一式三份的5 mL样品的抗微生物活性和稳定性。结果：在2周的时间内，与丁胺卡那霉素或万古霉素溶液相比，VA溶液的抑制区直径没有显着差异。目视检查表明，在整个研究期间，所有溶液在4摄氏度下均保持澄清，无色和无颗粒。对于渗透压，在所有测试时间中，VA溶液均比阿米卡星或万古霉素溶液高得多，并且更接近人眼的耐受范围。万古霉素，丁胺卡那霉素或VA溶液在第0、7或14天无显着差异。对于pH，VA溶液每次都高于万古霉素溶液（几乎等于阿米卡星溶液），并且更接近正常泪膜的水平。在所有测试时间中，万古霉素，丁胺卡那霉素或VA溶液的pH值均无显着差异。结论：万古霉素和丁胺卡那霉素眼药水可以混合在一起，具有相同的效力和稳定的物理性能。在临床试验中确定细菌性角膜炎的有效性和安全性可能很有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号