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Comparison of the effect of sertraline with behavioral therapy on semen parameters in men with primary premature ejaculation

机译：舍曲林与行为疗法对原发性早泄男性精液参数影响的比较

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Objective To investigate the effects of sertraline on semen parameters and comparison of its effect with behavioral therapy (BT) in men with primary premature ejaculation. Methods In this single-blinded clinical trial, a total of 60 married men with primary premature ejaculation were randomly divided into 2 groups: the sertraline group (n = 30, sertraline 25 mg/day for 1 week followed by 50 mg/day for 3 months) and the BT group (n = 30, using BT technique for 3 months). Semen analysis was applied, and the results were compared between groups before and 3 months after intervention. Results The significant reduction in sperm concentration (105/mL) and percentage of normal morphology was reported in sertraline group (P .05). The percentage of sperm deoxyribonucleic acid fragmentation after intervention in sertraline group was significantly higher than BT group (P =.004). There was no significant change in semen parameters in patients treated using BT. Conclusion Our study revealed detrimental effects of sertraline on some semen parameters. It should particularly be considered in patients who are trying to conceive. It seems BT is a safe method without any side effect on semen analysis parameters.
机译：目的探讨舍曲林对原发性早泄男性精液参数的影响，并与行为疗法（BT）进行比较。方法在该单盲临床试验中，将60名已婚原发性早泄的男性随机分为两组：舍曲林组（n = 30，舍曲林25 mg / day持续1周，随后50 mg / day持续3周）。个月）和BT组（n = 30，使用BT技术治疗3个月）。应用精液分析，并比较干预前和干预后3个月的结果。结果舍曲林组的精子浓度（105 / mL）和正常形态百分比显着降低（P <.05）。舍曲林组干预后精子脱氧核糖核酸碎裂的百分比显着高于BT组（P = .004）。使用BT治疗的患者精液参数没有显着变化。结论我们的研究揭示了舍曲林对某些精液参数的有害影响。试图受孕的患者应特别考虑使用它。 BT似乎是一种安全的方法，对精液分析参数没有任何副作用。

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