Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein

All Tavassoli; James E.S.Duffy; Douglas W.Young

首页> 外文期刊>Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry >Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein

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Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein

机译：三甲基（2S，3R）-和（2R，3R）-[2-〜2H_1]-同酸酯和相应的二甲基酯内酯的合成，从而阐明了由纯柠檬酸合酶和Nif-V蛋白催化的反应的立体化学

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Trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates,10b and 10c respectively,and dimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitric lactones,11b and 11e respectively,have been synthesised from shikimic acid and [2-~2H]-shikimic acid by a route which defines the stereochemistry of the two chiral centres in each compound.The NMR spectra of these products will enable the stereochemistry of the biological reaction catalysed by homocitrate synthase and by the protein from the nifV gene to be elucidated.

机译：三甲基（2S，3R）-和（2R，3R）-[2-〜2H_1]-同质物10b和10c，以及二甲基（2S，3R）-和（2R，3R）-[2-〜2H_1]- sh草酸和[2-〜2H] -shi草酸分别通过定义每种化合物中两个手性中心的立体化学路线合成了纯柠檬酸内酯11b和11e。这些产物的NMR光谱可实现立体化学由纯柠檬酸合酶和来自待阐明的nifV基因的蛋白质催化的生物反应。

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2005年第12期|共4页
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All Tavassoli; James E.S.Duffy; Douglas W.Young;
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1. Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein [J] . All Tavassoli, James E.S.Duffy, Douglas W.Young Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2005,第12期

机译：三甲基（2S，3R）-和（2R，3R）-[2-〜2H_1]-同酸酯和相应的二甲基酯内酯的合成，从而阐明了由纯柠檬酸合酶和Nif-V蛋白催化的反应的立体化学
2. Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein [J] . All Tavassoli, James E.S.Duffy, Douglas W.Young Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2005,第12期

机译：三甲基（2S，3R）-和（2R，3R）-[2-〜2H_1]-同酸酯和相应的二甲基酯内酯的合成，从而阐明了由纯柠檬酸合酶和Nif-V蛋白催化的反应的立体化学
3. Synthesis of trimethyl (2S,3R)- and (2R,3R)-[2-H-2(1)]-homocitrates and dimethyl (2S,3R)- and (2R,3R)-[2-H-2(1)]-homocitrate lactones - an assay for the stereochemical outcome of the reaction catalysed both by homocitrate synthase and by the Nif-V pr [J] . Tavassoli A, Duffy JES, Young DW Organic & biomolecular chemistry . 2006,第3期

机译：三甲基（2S，3R）-和（2R，3R）-[2-H-2（1）]-高纯酸酯和二甲基（2S，3R）-和（2R，3R）-[2-H-2（ 1）]-均聚内酯-通过均柠檬酸合酶和Nif-V pr催化催化反应的立体化学结果的方法
4. Synthesis of (2R,3S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-(4-bromophenyl)-3-(tert-butoxy-carbonylamino)-tetrahydrofuran-3-carboxylate and (2S,3R)-((1R,2S,5R)-2-isopropyl- 5-methylcyclohexyl)2-(4- bromophenyl)-3-(tert-butoxy¬carbonyl¬amino)-tetrahydrofuran-3-carboxylate [O] . Andreas Grauer, Burkhard König 2009

机译：（2R，3S）-（（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基羰基氨基）-四氢呋喃-3-羧酸酯的合成和（ 2S，3R）-（（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基羰基氨基）-四氢呋喃-3-羧酸酯

Synthesis of trimethyl(2S,3R)- and(2R,3R)-[2-~2H_1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein

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