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Heteropolymer translocation through nanopores

机译:杂聚物通过纳米孔易位

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The authors investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, they consider heteropolymers consisting of two types of monomers labeled A and B, which are distinguished by the magnitude of the driving force that they experience inside the pore. From a series of studies on polymers with sequences A(m)B(n) the authors identify both universal as well as specific sequence properties of the translocating chains. They find that the scaling of the average translocation time as a function of the chain length N remains unaffected by the heterogeneity, while the residence time of each bead is a strong function of the sequence for short repeat units. They further discover that for a symmetric heteropolymer A(n)B(n) of fixed length, the pattern exhibited by the residence times of the individual monomers has striking similarity with a double slit interference pattern where the total number of repeat units N/2n controls the number of interference fringes. These results are relevant for designing nanopore based sequencing techniques. (c) 2007 American Institute of Physics.
机译:作者研究了使用恒温Langevin恒温器通过纳米孔驱动的杂聚物的移位动力学。具体而言,他们考虑了由两种类型的标记为A和B的单体组成的杂聚物,它们的区别在于它们在孔内受到的驱动力大小。通过对具有序列A(m)B(n)的聚合物的一系列研究,作者确定了易位链的通用和特定序列特性。他们发现,平均易位时间的比例随链长N的变化仍然不受异质性的影响,而对于短重复单元,每个珠的停留时间是该序列的强函数。他们进一步发现,对于固定长度的对称杂聚物A(n)B(n),单个单体的停留时间所显示的图案与双缝干涉图案具有惊人的相似性,其中重复单元总数N / 2n控制干涉条纹的数量。这些结果与设计基于纳米孔的测序技术有关。 (c)2007年美国物理研究所。

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