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首页> 外文期刊>The Journal of Chemical Physics >Peculiar surface behavior of some ionic liquids based on active pharmaceutical ingredients
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Peculiar surface behavior of some ionic liquids based on active pharmaceutical ingredients

机译：基于活性药物成分的某些离子液体的特殊表面行为

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摘要

The ionic liquids based on biologically active cations and anions, commonly designated by ionic liquids based on active pharmaceutical ingredients (ILs-APIs), are interesting compounds for use in pharmaceutical applications. Lidocaine docusate, ranitidine docusate, and didecyldimethylammonium ibuprofen are examples of promising ILs-APIs that were recently synthesized. They were submitted to biological testing and calorimetric measurements, but nothing is known about their surface properties. In this work, we measured the surface tension and the contact angles on both hydrophilic and hydrophobic surfaces in a temperature range as wide as possible. Based on the wettability data, the polarity fractions were estimated using the Fowkes theory. The peculiar surface behavior observed was tentatively attributed to the presence of mesophases.
机译：基于生物活性阳离子和阴离子的离子液体，通常被称为基于活性药物成分（ILs-API）的离子液体，是用于药物应用的令人感兴趣的化合物。利多卡因多库酯，雷尼替丁多库酯和二癸基二甲基铵布洛芬是最近合成的有前途的ILs-API的例子。他们已经接受了生物学测试和量热测量，但对其表面性质一无所知。在这项工作中，我们在尽可能宽的温度范围内测量了亲水性和疏水性表面上的表面张力和接触角。根据润湿性数据，使用Fowkes理论估算极性分数。观察到的特殊表面行为暂时归因于中间相的存在。

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