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首页> 外文期刊>The Journal of Immunology: Official Journal of the American Association of Immunologists >Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8~+T Cells
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Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8~+T Cells

机译：Bcl6充当中央记忆CD8〜+ T细胞的产生和增殖能力的放大器

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Central memory CD8~+T cells(T_CM)are considered to be more efficient than effector ones(T_EM)for mediating protective immunity.The molecular mechanism involved in the generation of these cells remains elusive.Because Bcl6 plays a role in the generation and maintenance of memory CD8~+T cells,we further examined this role in the process in relation to T_CM and T_EM subsets.In this study,we show that T_CM and T_EM were functionally identified in CD62L~+and CD62L~-memory(CD44~+Ly6C~+)CD8~+T cell subsets,respectively.Although T_CM produced similar amounts of IFN-y and IL-2 to TEM after anti-CD3 stimulation,the cell proliferation capacity after stimulation and tissue distribution profiles of TCM differed from those of T_EM.Numbers of T_CM were greatly reduced and elevated in spleens of Bcl6-deficient and lcA>Bcl6 transgenic mice,respectively,and those of T_EM were constant in nonlymphoid organs of these same mice.The majority of Ag-specific memory CD8~+T cells in spleens of these mice 10 wk after immunization were T_CM,and the number correlated with Bcl6 expression in T cells.The proliferation of Ag-specific memory CD8~+T cells upon secondary stimulation was dramatically up-regulated in lck-Bcl6 transgenic mice,and the adoptive transfer experiments with Ag-specific naive CD8~+T cells demonstrated that some of the up-regulation was due to the intrinsic effect of Bcl6 in the T cells.Thus,Bcl6 is apparently a crucial factor for the generation and secondary expansion of T_CM.
机译：中央记忆CD8〜+ T细胞（T_CM）在介导保护性免疫方面被认为比效应细胞（T_EM）更有效，这些细胞的生成所涉及的分子机制仍然难以捉摸，因为Bcl6在生成和维持中起着重要作用。在记忆CD8〜+ T细胞中，我们进一步研究了T_CM和T_EM子集在此过程中的作用。尽管T_CM在抗CD3刺激后与TEM产生相似量的IFN-y和IL-2，但T_CM刺激后的细胞增殖能力和中药的组织分布特征却与TCM的不同。 T_EM。分别在Bcl6缺陷型和lcA> Bcl6转基因小鼠的脾脏中T_CM的数目大大减少和升高，并且在这些相同小鼠的非淋巴器官中T_EM的数目恒定。大多数Ag特异性记忆CD8〜+ T这些小鼠脾脏中的细胞10周免疫后的T_CM，数目与T细胞中Bcl6的表达有关。lck-Bcl6转基因小鼠继发刺激后，Ag特异性记忆CD8〜+ T细胞的增殖明显上调，并且Ag的过继转移实验特异的天然CD8〜+ T细胞表明某些上调是由于Bcl6在T细胞中的内在作用所致。因此，Bcl6显然是T_CM产生和继发扩增的关键因素。

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