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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Spatially distinct functional output regions within the central nucleus of the inferior colliculus: implications for an auditory midbrain implant.
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Spatially distinct functional output regions within the central nucleus of the inferior colliculus: implications for an auditory midbrain implant.

机译：下丘脑中央核内空间上不同的功能输出区域：对听觉中脑植入物的影响。

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The inferior colliculus central nucleus (ICC) has potential as a new site for an auditory prosthesis [i.e., auditory midbrain implant (AMI)] for deaf patients who cannot benefit from cochlear implants (CIs). We have previously shown that ICC stimulation achieves lower thresholds, greater dynamic ranges, and more localized, frequency-specific primary auditory cortex (A1) activation than CI stimulation. However, we also observed that stimulation location along the caudorostral (isofrequency) dimension of the ICC affects thresholds and frequency specificity in A1, suggesting possible differences in functional (output) organization within the ICC. In this study, we electrically stimulated different regions along the isofrequency laminas of the ICC and recorded the corresponding A1 activity in ketamine-anesthetized guinea pigs using multisite probes to systematically assess ICC stimulation location effects. Our results indicate that stimulation of more rostral and somewhat ventral regions within an ICC lamina achieves lower thresholds, smaller discriminable level steps, and larger evoked potentials in A1. We also observed longer first spike latencies, which correlated with reduced spiking precision, when stimulating in more caudal and dorsal ICC regions. These findings suggest that at least two spatially distinct functional output regions exist along an ICC lamina: a caudal-dorsal region and a rostral-ventral region. The AMI will be implanted along the tonotopic axis of the ICC to achieve frequency-specific activation. However, stimulation location along the ICC laminas affects response properties that have shown to be important for speech perception performance, and needs to be considered when implanting future AMI patients.
机译：对于无法受益于人工耳蜗（CIs）的聋哑患者，下丘脑中央核（ICC）有潜力成为听觉假体[即听觉中脑植入物（AMI）]的新场所。先前我们已经证明，与CI刺激相比，ICC刺激可实现更低的阈值，更大的动态范围以及更局部的，特定于频率的主听皮层（A1）激活。但是，我们还观察到，沿ICC沿柔毛线（等频率）方向的刺激位置会影响A1的阈值和频率特异性，提示ICC内功能（输出）组织的可能差异。在这项研究中，我们电刺激了ICC等速层的不同区域，并使用多部位探针系统地评估了ICC刺激定位效果，从而在氯胺酮麻醉的豚鼠中记录了相应的A1活性。我们的结果表明，在ICC椎板内刺激更多的鸟嘴状区域和一些腹侧区域，可实现A1的较低阈值，较小的可分辨水平步长和较大的诱发电位。当在更多的尾部和背侧ICC区域进行刺激时，我们还观察到更长的首次峰潜伏期，这与降低的峰值精度相关。这些发现表明，沿着ICC椎板存在至少两个在空间上不同的功能输出区域：尾-背区域和头-腹区域。 AMI将沿着ICC的异位轴植入，以实现特定于频率的激活。但是，沿着ICC椎板的刺激位置会影响响应性能，这已显示出对于语音感知性能很重要，因此在植入未来的AMI患者时需要予以考虑。

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