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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Frequency-tuned distribution of inhibition in the dentate gyrus.
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Frequency-tuned distribution of inhibition in the dentate gyrus.

机译：频率调节的齿状回中抑制的分布。

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摘要

Granule cells (GCs) of the dentate gyrus use sparse encoding to perform redundancy reduction, pattern separation, and novelty detection. One likely candidate mechanism to enforce low spiking activity is feedforward inhibition, in which the cortical excitatory drive from the perforant path (PP) recruits GABAergic interneurons that then inhibit GCs. Little is known, however, about how PP drive is balanced between GCs versus inhibitory neurons. In simultaneous recordings of GCs and fast-spiking (FS) interneurons from C57BL/6 mice, we find that focal PP stimulation preferentially recruits spiking in FS interneurons over GCs, because GCs require a larger excitatory synaptic current density to reach spike threshold. Blocking inhibition reversed this relationship, revealing a stronger intrinsic coupling between the PP and GCs versus FS interneurons and showing that inhibition can sparsify the output of the dentate gyrus by tightly regulating GC spike probability. Moreover, this regulation is dynamic, because the spiking profile of FS interneurons was frequency tuned, displaying bursting behavior in response to PP stimulation near theta rhythm frequency ( approximately 10 Hz). The later spikes in the bursts were part of the feedback inhibitory pathway because they were driven by late EPSCs, were blocked by an inhibitor of synaptic output from GCs, and shared the same frequency dependence as GC spiking. Therefore, the temporal content of signals arriving via the PP determines whether a FS interneuron participates in only feedforward (one spike) or both feedforward and feedback (burst) inhibition.
机译：齿状回的颗粒细胞（GC）使用稀疏编码来执行冗余减少，模式分离和新颖性检测。强制执行低加标活性的一种可能的候选机制是前馈抑制，其中来自穿孔路径（PP）的皮质兴奋性驱动募集了GABA能性神经元，该神经元随后抑制了GC。然而，关于如何在GC与抑制性神经元之间平衡PP驱动力知之甚少。在同时记录来自C57BL / 6小鼠的GC和快速加标（FS）中间神经元的过程中，我们发现，与PP相比，聚焦PP刺激优先招募FS中间神经元的尖峰，因为GC需要更大的兴奋性突触电流密度才能达到尖峰阈值。阻滞抑制逆转了这种关系，揭示了PP和GC相对于FS中神经元之间更强的内在耦合，并表明抑制可以通过严格调节GC尖峰概率来稀疏齿状回的输出。此外，该调节是动态的，因为对FS中间神经元的突波分布进行了频率调谐，响应于PP刺激在theta节奏频率（约10 Hz）附近表现出爆发行为。爆发中的后期尖峰是反馈抑制途径的一部分，因为它们是由晚期EPSC驱动，被GC的突触输出抑制剂所阻断，并具有与GC尖峰相同的频率依赖性。因此，通过PP到达的信号的时间内容确定FS内部神经元是仅参与前馈（一个尖峰）还是参与前馈和反馈（突发）抑制。

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