...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.
【24h】

Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.

机译：加压素在人类情绪处理过程中调节内侧前额叶皮层-杏仁核回路。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The neuropeptide vasopressin is a modulator of mammalian social behavior and emotion, particularly fear, aggression, and anxiety. In humans, the neural circuitry underlying behavioral effects of vasopressin is unknown. Using a double-blind crossover administration of 40 IU of vasopressin or placebo and functional MRI during processing of facial emotions in healthy male volunteers, we show that vasopressin specifically reduces differential activation in the subgenual cingulate cortex. Structural equation modeling of a previously evaluated circuit between amygdala, subgenual cingulate, and supragenual cingulate revealed altered effective connectivity between subgenual and supragenual cingulate under vasopressin. Our data demonstrate an impact of vasopressin on activity and connectivity in the cortical component of a medial prefrontal cortex-amygdala circuit implicated in emotional regulation, providing the first data on the neural basis for the effects of vasopressin on social behavior in humans with potential therapeutic significance for mood and anxiety disorders.
机译：神经肽加压素是哺乳动物社交行为和情绪，特别是恐惧，侵略和焦虑的调节剂。在人类中，加压素行为作用的神经回路尚不清楚。在健康男性志愿者的面部表情处理过程中，使用40 IU加压素或安慰剂和功能性MRI进行双盲交叉给药，我们显示出加压素可特异性降低舌下扣带回皮层的差异激活。杏仁核，舌下扣带回和舌上扣带回之间先前评估的电路的结构方程模型表明，在加压素的作用下，舌下和舌上扣带回之间的有效连通性发生了变化。我们的数据证明了加压素对涉及情绪调节的内侧前额叶皮层-杏仁核回路皮质组件活动和连通性的影响，为血管加压素对人类社会行为的影响提供了神经基础的首个数据，具有潜在的治疗意义。用于情绪和焦虑症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号