...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Syntaxin1A lateral diffusion reveals transient and local SNARE interactions.
【24h】

Syntaxin1A lateral diffusion reveals transient and local SNARE interactions.

机译：Syntaxin1A横向扩散揭示了瞬态和局部SNARE相互作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

At the synapse, vesicles stably dock at the active zone. However, in cellular membranes, proteins undergo a diffusive motion. It is not known how the motion of membrane proteins involved in vesicle exocytosis is compatible with both vesicle docking and the dynamic remodeling of the plasma membrane imposed by cycles of exocytosis and endocytosis. To address this question, we studied the motion of the presynaptic membrane protein syntaxin1A at both the population and single-molecule levels in primary cultures of rat spinal cord neurons. Syntaxin1A was rapidly exchanged between synaptic and extrasynaptic regions. Changes in syntaxin1A mobility were associated with interactions related to the formation of the exocytotic complex. Finally, we propose a reaction-diffusion model reconciling the observed diffusive properties of syntaxin at the population level and at the molecular level. This work allows us to describe the diffusive behavior and kinetics of interactions between syntaxin1A and its partners that lead to its transient stabilization at the synapse.
机译：在突触处，囊泡稳定地停靠在活动区。但是，在细胞膜中，蛋白质会发生扩散运动。尚不知道参与囊泡胞吐作用的膜蛋白的运动如何与囊泡对接以及胞吐作用和胞吞作用的周期对质膜的动态重塑兼容。为了解决这个问题，我们研究了大鼠脊髓神经元原代培养物中突触前膜蛋白syntaxin1A在群体和单分子水平上的运动。 Syntaxin1A在突触和突触外区域之间迅速交换。 Syntaxin1A迁移率的变化与胞吐复合物的形成有关。最后，我们提出了一个反应扩散模型，用于协调在人口水平和分子水平观察到的syntaxin的扩散特性。这项工作使我们能够描述syntaxin1A及其合作伙伴之间相互作用的扩散行为和动力学，从而导致其在突触处的瞬时稳定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号