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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit.
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Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit.

机译：多巴胺受体介导的鸦片奖励记忆开关在基底外侧杏仁核-伏隔核回路中的鉴定。

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摘要

The basolateral amygdala (BLA), ventral tegmental area (VTA), and nucleus accumbens (NAc) play central roles in the processing of opiate-related associative reward learning and memory. The BLA receives innervation from dopaminergic fibers originating in the VTA, and both dopamine (DA) D1 and D2 receptors are expressed in this region. Using a combination of in vivo single-unit extracellular recording in the NAc combined with behavioral pharmacology studies, we have identified a double dissociation in the functional roles of DA D1 versus D2 receptor transmission in the BLA, which depends on opiate exposure state; thus, in previously opiate-naive rats, blockade of intra-BLA D1, but not D2, receptor transmission blocked the acquisition of associative opiate reward memory, measured in an unbiased conditioned place preference procedure. In direct contrast, in rats made opiate dependent and conditioned in a state of withdrawal, intra-BLA D2, but not D1, receptor blockade blocked opiate reward encoding. This functional switch was dependent on cAMP signaling as comodulation of intra-BLA cAMP levels reversed or replicated the functional effects of intra-BLA D1 or D2 transmission during opiate reward processing. Single-unit in vivo extracellular recordings performed in neurons of the NAc confirmed an opiate-state-dependent role for BLA D1/D2 transmission in NAc neuronal response patterns to morphine. Our results characterize and identify a novel opiate addiction switching mechanism directly in the BLA that can control the processing of opiate reward information as a direct function of opiate exposure state via D1 or D2 receptor signaling substrates.
机译：基底外侧杏仁核（BLA），腹侧被盖区（VTA）和伏隔核（NAc）在与阿片剂相关的联想奖励学习和记忆的处理中起着核心作用。 BLA接收来自VTA的多巴胺能纤维的神经支配，并且多巴胺（DA）D1和D2受体均在该区域表达。通过结合使用NAc中的体内单单元细胞外记录和行为药理学研究，我们已经确定了DA D1对BLA中D2受体传递的功能作用有双重解离，这取决于阿片类药物的暴露状态;因此，在以前没有鸦片制剂的大鼠中，BLA内D1而不是D2的阻滞，受体传递会阻止获得相关的鸦片制剂奖励记忆，这是在无偏见的条件性场所偏爱程序中测得的。与之形成鲜明对比的是，在大鼠中，鸦片依赖并处于戒断状态，BLA内D2而非D1受体阻滞剂阻断了鸦片奖励编码。此功能转换取决于cAMP信号，因为在鸦片制剂奖励过程中，BLA内cAMP水平的共调节逆转或复制了BLA内D1或D2传递的功能效应。在NAc的神经元中进行的单单位体内细胞外记录证实了吗啡在NAc神经元反应模式中BLA D1 / D2传递的鸦片状态依赖性作用。我们的研究结果表征并直接在BLA中确定了一种新型的鸦片成瘾转换机制，该机制可以通过D1或D2受体信号传递底物将鸦片奖励信息的处理作为鸦片暴露状态的直接函数进行控制。

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