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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal
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Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal

机译：长期降低Gamma功率可预测负BOLD信号背后的血流动力学变化

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摘要

Studies that use prolonged periods of sensory stimulation report associations between regional reductions in neural activity and negative blood oxygenation level-dependent (BOLD) signaling. However, the neural generators of the negative BOLD response remain to be characterized. Here, we use single-impulse electrical stimulation of the whisker pad in the anesthetized rat to identify components of the neural response that are related to "negative" hemodynamic changes in the brain. Laminar multiunit activity and local field potential recordings of neural activity were performed concurrently with two-dimensional optical imaging spectroscopy measuring hemodynamic changes. Repeated measurements over multiple stimulation trials revealed significant variations in neural responses across session and animal datasets. Within this variation, we found robust long-latency decreases (300 and 2000 ms after stimulus presentation) in gamma-band power (30-80 Hz) in the middle-superficial cortical layers in regions surrounding the activated whisker barrel cortex. This reduction in gamma frequency activity was associated with corresponding decreases in the hemodynamic responses that drive the negative BOLD signal. These findings suggest a close relationship between BOLD responses and neural events that operate over time scales that outlast the initiating sensory stimulus, and provide important insights into the neurophysiological basis of negative neuroimaging signals.
机译：使用长时间的感觉刺激的研究报告了神经活动的区域性减少与负性血液氧合水平依赖性（BOLD）信号之间的关联。但是，负大胆反应的神经发生器仍有待表征。在这里，我们使用麻醉大鼠的晶须垫的单脉冲电刺激，以识别与大脑中“负”血流动力学变化相关的神经反应成分。层流多单位活动和神经活动的局部场电位记录与二维光学成像光谱仪同时测量血流动力学变化。多次刺激试验的重复测量表明，整个实验和动物数据集的神经反应存在显着差异。在此变化范围内，我们发现激活晶须桶皮层周围区域的中上层皮质层中，伽马波段功率（30-80 Hz）的鲁棒性长时延降低（刺激显示后300和2000 ms）。伽马频率活动的降低与驱动负BOLD信号的血液动力学响应相应降低有关。这些发现表明，大胆的反应和神经事件之间存在密切的关系，该神经事件的发生时间超过了起始的感觉刺激，并为阴性神经影像信号的神经生理学基础提供了重要的见识。

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