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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons
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Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons

机译：Prox1调节尾神经节隆起衍生的GABA能皮层interneurons的亚型特定发展。

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摘要

Neurogliaform (RELN+) and bipolar (VIP+) GABAergic interneurons of the mammalian cerebral cortex provide critical inhibition locally within the superficial layers. While these subtypes are known to originate from the embryonic caudal ganglionic eminence (CGE), the specific genetic programs that direct their positioning, maturation, and integration into the cortical network have not been elucidated. Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 impairs the integration of these cells into superficial layers. Moreover, Prox1 differentially regulates the postnatal maturation of each specific subtype originating from the CGE (RELN, Calb2/VIP, and VIP). Interestingly, Prox1 promotes the maturation of CGE-derived interneuron subtypes through intrinsic differentiation programs that operate in tandem with extrinsically driven neuronal activity-dependent pathways. Thus Prox1 represents the first identified transcription factor specifically required for the embryonic and postnatal acquisition of CGE-derived cortical interneuron properties.
机译：哺乳动物大脑皮层的神经胶质（RELN +）和双极（VIP +）GABA能中间神经元在浅表层局部提供了关键的抑制作用。虽然已知这些亚型起源于胚胎尾神经节隆起（CGE），但尚未阐明指导其定位，成熟和整合到皮质网络中的特定遗传程序。在这里，我们报告在小鼠中转录因子Prox1的表达选择性地维持在有丝分裂后CGE衍生的皮质中间神经元前体中，并且Prox1的缺失会损害这些细胞整合到浅层中。此外，Prox1差异性调节源自CGE（RELN，Calb2 / VIP和VIP）的每个特定亚型的产后成熟。有趣的是，Prox1通过内在分化程序与外在驱动的神经元活动依赖性途径协同工作，促进了CGE衍生的中间神经元亚型的成熟。因此，Prox1代表了CGE衍生的皮质中间神经元特性的胚胎和出生后采集特别需要的第一个鉴定的转录因子。

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