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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy
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Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy

机译：进行性，癫痫样发作，波状放电在受伤和未受伤的Sprague-Dawley大鼠中均很常见：对创伤性癫痫后液体冲击损伤模型的影响

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Variable-duration oscillations and repetitive, high-voltage spikes have been recorded in the electrocorticogram (ECoG) of rats weeks and months after fluid percussion injury (FPI), a model of traumatic brain injury. These ECoG events, which have many similarities to spike-wave-discharges (SWDs) and absence seizures, have been proposed to represent nonconvulsive seizures characteristic of post-traumatic epilepsy (PTE). The present study quantified features of SWD episodes in rats at different time points after moderate to severe FPI, and compared them with age-matched control rats. Control and FPI-injured rats at 1 year of age displayed large-amplitude and frequent SWD events at frontal and parietal recording sites. At 3-6 months, SWDs were shorter in duration and less frequent; extremely brief SWDs (i.e., "larval") were detected as early as 1 month. The onset of the SWDs was nearly always synchronous across electrodes and of larger amplitude in frontal regions. A sensory stimulus, such as a click, immediately and consistently stopped the occurrence of the SWDs. SWDs were consistently accompanied by behavioral arrest. All features of SWDs in control and experimental (FPI) rats were indistinguishable. None of the FPI-treated rats developed nonconvulsive or convulsive seizures that could be distinguished electro-graphically or behaviorally from SWDs. Because SWDs have features similar to genetic absence seizures, these results challenge the hypothesis that SWDs after FPI reflect PTE.
机译：流体冲击损伤（FPI）（一种脑外伤模型）在数周和数月后，在大鼠的皮质电图（ECoG）中记录了持续时间变化的振荡和反复出现的高压尖峰。这些ECoG事件与尖峰波放电（SWD）和无癫痫发作有很多相似性，已被认为代表创伤后癫痫（PTE）的非惊厥性癫痫发作。本研究量化了中度至重度FPI后不同时间点大鼠SWD发作的特征，并将其与年龄匹配的对照大鼠进行了比较。 1岁大的对照组和FPI损伤的大鼠在额叶和顶叶记录部位显示出大幅度和频繁的SWD事件。在3到6个月时，社署的病程较短且频率较低;最早1个月就检测到非常简短的SWD（即“幼虫”）。 SWD的发作几乎总是在电极之间同步，并且在额叶区域幅度更大。感觉上的刺激（如咔嗒声）立即并持续地阻止了SWD的发生。社署始终伴随着行为逮捕。对照和实验（FPI）大鼠中SWD的所有特征均无法区分。 FPI治疗的大鼠均未出现非惊厥性或惊厥性癫痫发作，可以通过电子图形或行为方式与SWD进行区分。由于SWD具有与遗传性癫痫发作相似的特征，因此这些结果挑战了FPI后SWD反映PTE的假设。

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