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首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >Vitamin B2 in Nanoscopic Environments under Visible Light: Photosensitized Antioxidant or Phototoxic Drug?
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Vitamin B2 in Nanoscopic Environments under Visible Light: Photosensitized Antioxidant or Phototoxic Drug?

机译：可见光下纳米环境中的维生素B2：光敏抗氧化剂还是光毒性药物？

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摘要

Vitamin B2 has been studied as a conventional antioxidant (in the dark) since its discovery in 1926. The effect of visible light on vitamin B2-containing food has a long history of scientific investigation. Although photodegradation of the vitamin producing several photoproducts is evident in certain experimental conditions, phototoxicity revealing an additional oxidative stress in the medium is also clear from some reports. Here we report the photosensitized antioxidant effect of the vitamin, which is found to be greater than 2 orders of magnitude more efficient than that in the dark condition. The photoinduced antioxidant property is apparently paradoxical compared to the reported phototoxic effect of the vitamin. Our present study unravels a unified picture underlying the difference in character of vitamin B_2 under visible light irradiation. UV?vis absorption and fluorescence studies in a number of physiologically relevant nanoscopic environments (micelles and reverse micelles) reveal the antioxidant activity to a wellknown oxidative stress marker 2,2-diphenyl-1-picrylhydrazyl (DPPH) as well as a phototoxicity effect resulting in self-degradation of the vitamin. Picosecond-resolved Fo?rster resonance energy transfer (FRET) from the vitamin to the marker DPPH in the biomimetic environments clearly reveals the role of proximity of an oxidizing agent in the photoinduced effect of the vitamin. Our systematic and detailed studies unravel a simple picture of the mechanistic pathway of the photosensitized vitamin in the physiologically important environments leading to the antioxidant/phototoxicity effect of the vitamin. The excited vitamin transfers its electron to the oxidizing agent in proximity for the antioxidant effect, but otherwise it employs oxygen to generate reactive oxygen species (ROS), resulting in phototoxicity/self-degradation.
机译：自1926年发现维生素B2以来，就一直将其作为常规抗氧化剂（在黑暗中）进行研究。可见光对含维生素B2的食品的影响已有很长的科学研究历史。尽管在某些实验条件下会明显降解产生几种光产物的维生素，但是从某些报道中也可以清楚地看到光毒性表明介质中存在额外的氧化应激。在这里，我们报告了维生素的光敏抗氧化作用，发现它比黑暗条件下的光效高2个数量级。与所报道的维生素的光毒性作用相比，光诱导的抗氧化剂性质显然是矛盾的。我们目前的研究揭示了可见光照射下维生素B_2特性差异的统一图景。在许多生理相关的纳米环境（胶束和反胶束）中的UV-vis吸收和荧光研究揭示了对众所周知的氧化应激标记2,2-二苯基-1-吡啶并肼基（DPPH）的抗氧化活性以及所产生的光毒性作用会自行降解维生素。在仿生环境中从维生素到标记DPPH的皮秒分辨的福斯特共振能量转移（FRET）清楚地揭示了氧化剂在维生素的光诱导作用中的作用。我们的系统详细研究揭示了光敏维生素在重要生理环境中导致维生素的抗氧化/光毒性作用的机理途径的简单图景。被激发的维生素将其电子转移到附近的氧化剂中以产生抗氧化作用，但否则它会利用氧气产生活性氧（ROS），从而导致光毒性/自降解。

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