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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >A detailed look at vesicle fusion
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A detailed look at vesicle fusion

机译：囊泡融合的详细介绍

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Many different hypotheses on the molecular mechanisms of vesicle fusion exist. Because these mechanisms cannot be readily asserted experimentally, we address the problem by a coarse-grained molecular dynamics simulations study and compare the results with the results of other techniques. The simulations performed include the fusion of small and large vesicles and exocytosis, i.e., the fusion of small vesicles with flat bilayers. We demonstrate that the stalk, the initial contact between two fusing vesicles, is initiated by lipid tails that extend spontaneously. The stalk is revealed to be composed of the contacting monolayers only, yet without hydrophobic voids. Anisotropic and radial expansion of the stalk have been theorized; we show that stalk evolution can proceed via both pathways starting from similar setups and that water triggers the transition from elongated stalk to hemifusion diaphragm.
机译：关于囊泡融合的分子机制存在许多不同的假设。由于无法轻易通过实验断言这些机制，因此我们通过粗粒度分子动力学模拟研究解决了该问题，并将结果与​​其他技术的结果进行了比较。进行的模拟包括小囊泡和大囊泡的融合和胞吐作用，即小囊泡与平坦双层的融合。我们证明茎，两个融合囊泡之间的初始接触，是由自发延伸的脂质尾巴引发的。茎被发现仅由接触的单层组成，而没有疏水性空隙。对茎的各向异性和径向膨胀进行了理论分析;我们表明，茎的进化可以通过两种途径从相似的设置开始进行，并且水触发了从细长的茎到半融合隔膜的过渡。

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