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首页> 外文期刊>The journal of physical chemistry, C. Nanomaterials and interfaces >Targeted Combinatorial Therapy Using Gold Nanostars as Theranostic Platforms
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Targeted Combinatorial Therapy Using Gold Nanostars as Theranostic Platforms

机译：使用金纳米星作为治疗学平台的靶向组合治疗

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This paper reports the development of a multimodal therapy nanoplatform based on gold nanostars (Au NS) as core particles. These NS were functionalized with the chemotherapeutic drug doxorubicin (DOXO), which was conjugated to the NS surface by means of a cleavable heterobifunctional cross-linker (sulfo-LC-SPDP) to allow its release under the action of reducing enzymes. To ensure a specific delivery of the chemotherapeutic drug, the nanoplatform was additionally functionalized with folic acid (FA) as targeting ligand and cellular uptake adjuvant. By synthetically modifying the plasmon band of Au NS to the near-infrared (NIR) region of the electromagnetic spectrum, the present nanoplatform was able to simultaneously combine the capability of photothermal therapy (PTT) through the conversion of absorbed light energy into localized heat and chemotherapy, enabling their monitoring by means of optical fluorescence imaging thanks to DOXO's autofluorescence. Cellular uptake was observed to be enhanced when the Au NPs were decorated with the targeting ligand. In addition, the therapeutic efficiency of the nanoplatform tested in HeLa cells demonstrated the larger cytotoxicity efficiency of the combined therapy if compared to individual ones.
机译：本文报道了基于金纳米星（Au NS）作为核心颗粒的多峰疗法纳米平台的开发。这些NS用化疗药物阿霉素（DOXO）功能化，阿霉素通过可裂解的异双功能交联剂（sulfo-LC-SPDP）与NS表面偶联，使其在还原酶的作用下释放。为了确保化学治疗药物的特异性递送，还用叶酸（FA）作为靶向配体和细胞摄取佐剂对纳米平台进行了功能化。通过将Au NS的等离激元带合成修饰到电磁波谱的近红外（NIR）区域，本纳米平台能够通过将吸收的光能转换为局部热和热能同时结合光热疗法（PTT）的功能。化疗，借助DOXO的自发荧光，可以通过光学荧光成像进行监测。当用靶向配体修饰Au NP时，细胞摄取被增强。另外，在HeLa细胞中测试的纳米平台的治疗效率证明了与单独治疗相比，联合治疗具有更大的细胞毒性效率。

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