Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila

Lovegrove B; Simoes S; Rivas ML; SotilloS S; Johnson K; Knust E; Jacinto A; Hombria JCG

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Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila

机译：细胞粘附，极性和细胞骨架的协调控制是果蝇中Hox诱导的器官发生的基础。

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Background: Hox genes control animal body plans by directing the morphogenesis of segment-specific structures. As transcription factors, HOX proteins achieve this through the activation of downstream target genes. Much research has been devoted to the search for these targets and the characterization of their roles in organogenesis. This has shown that the direct targets of Hox activation are often transcription factors or signaling molecules, which form hierarchical genetic networks directing the morphogenesis of particular organs. Importantly, very few of the direct Hox targets known are "realizator" genes involved directly in the cellular processes of organogenesis.

机译：背景：Hox基因通过指导节段特异性结构的形态发生来控制动物的身体计划。作为转录因子，HOX蛋白通过激活下游靶基因来实现这一目标。已经进行了大量研究以寻找这些靶标并表征它们在器官发生中的作用。这表明Hox激活的直接靶标通常是转录因子或信号分子，它们形成指导特定器官形态发生的分级遗传网络。重要的是，几乎没有直接的Hox靶标是直接参与器官发生细胞过程的“实现子”基因。

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《Current Biology: CB》 |2006年第22期|共11页
作者
Lovegrove B; Simoes S; Rivas ML; SotilloS S; Johnson K; Knust E; Jacinto A; Hombria JCG;
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正文语种 eng
中图分类生物科学;
关键词
BITHORAX COMPLEX; EMPTY SPIRACLES; GENE-FUNCTION; E-CADHERIN; MORPHOGENESIS; PROTEIN; CRUMBS; EXPRESSION; EPITHELIA; ENCODES;

机译：甲HOR络合物;空灵;基因功能;E-钙粘蛋白;产热;蛋白质;面包屑;表达;上皮;编码;

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1. Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila [J] . Lovegrove B, Simoes S, Rivas ML, Current Biology: CB . 2006,第22期

机译：细胞粘附，极性和细胞骨架的协调控制是果蝇中Hox诱导的器官发生的基础。
2. Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster [J] . Venugopal Parvathy, Veyssière Hugo, Couderc Jean-Louis, BMC Developmental Biology . 2020,第a期

机译：支架蛋白质圆盘大的多种功能，在果蝇的生长，细胞极性和细胞粘附中的控制中的含量
3. Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts [J] . A. J. Hudspeth, Ivana Mirkovic, Serhiy Pylawka Biology Open . 2012,第5期

机译：分化的毛细胞之间的重排协调平面极性和侧线神经质中的镜像对称性的建立分化的毛细胞之间的重排协调平面极性和侧线神经质中的镜像对称性的建立侧线神经质的镜面对称
4. Analysis of cytoskeleton dynamics and cell migration in drosophila ovaries using GFP-actin and E-cadherin-GFP fusion molecules [C] . Vladyslav V. Verkhusha, Japan Science Technology Corp., Kyoto Shimogyo-ku, Conference on optical diagnostics of living cells . 1999

机译：使用GFP-肌动蛋白和E-钙粘蛋白-GFP融合分子分析果蝇卵巢中的细胞骨架动力学和细胞迁移
5. Epithelial cell polarity and proliferation control in Drosophila melanogaster. [D] . Morrison, Holly Ann. 2010

机译：果蝇的上皮细胞极性和增殖控制。
6. Cell polarity cell adhesion and spermatogenesis: role of cytoskeletons [O] . Linxi Li, Ying Gao, Haiqi Chen, -1

机译：细胞极性细胞粘附和生精：细胞骨架的作用
7. Coordinated Control of Cell Adhesion, Polarity, and Cytoskeleton Underlies Hox-Induced Organogenesis in Drosophila [O] . Lovegrove, Bridget, Simões, Sergio, Rivas, María Luisa, 2006

机译：细胞粘附，极性和细胞骨架的协调控制是果蝇中Hox诱导器官发生的基础。

Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila

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