• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The New England journal of medicine >Lifestyle change and mobility in obese adults with type 2 diabetes
【24h】

Lifestyle change and mobility in obese adults with type 2 diabetes

机译：肥胖的2型糖尿病成年人的生活方式变化和活动能力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND:Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobility in such patients. METHODS:We randomly assigned 5145 overweight or obese adults between the ages of 45 and 74 years with type 2 diabetes to either an intensive lifestyle intervention or a diabetes support-and-education program; 5016 participants contributed data. We used hidden Markov models to characterize disability states and mixed-effects ordinal logistic regression to estimate the probability of functional decline. The primary outcome was self-reported limitation in mobility, with annual assessments for 4 years. RESULTS:At year 4, among 2514 adults in the lifestyle-intervention group, 517 (20.6%) had severe disability and 969 (38.5%) had good mobility; the numbers among 2502 participants in the support group were 656 (26.2%) and 798 (31.9%), respectively. The lifestyle-intervention group had a relative reduction of 48% in the risk of loss of mobility, as compared with the support group (odds ratio, 0.52; 95% confidence interval, 0.44 to 0.63; P<0.001). Both weight loss and improved fitness (as assessed on treadmill testing) were significant mediators of this effect (P<0.001 for both variables). Adverse events that were related to the lifestyle intervention included a slightly higher frequency of musculoskeletal symptoms at year 1. CONCLUSIONS:Weight loss and improved fitness slowed the decline in mobility in overweight adults with type 2 diabetes. (Funded by the Department of Health and Human Services and others; ClinicalTrials.gov number, NCT00017953.)
机译：背景：患有2型糖尿病的成年人的活动能力通常会随着年龄的增长而受到限制。强烈的生活方式干预会导致体重减轻并改善健康状况，可能会减慢此类患者的行动能力丧失。方法：我们随机分配5145名年龄在45至74岁之间的2型糖尿病超重或肥胖成年人参加强化生活方式干预或糖尿病支持和教育计划; 5016位参与者提供了数据。我们使用隐马尔可夫模型来表征残疾状态，并使用混合效应序数逻辑回归来估计功能下降的可能性。主要结果是自我报告的行动不便，并进行了为期4年的年度评估。结果：在第4年，生活方式干预组的2514名成年人中，有517名（20.6％）患有严重残疾，而969名（38.5％）则具有良好的活动能力;支持组的2502名参与者分别为656（26.2％）和798（31.9％）。与支持组相比，生活方式干预组的行动不便风险相对降低了48％（优势比为0.52; 95％的置信区间为0.44至0.63; P <0.001）。体重减轻和健康状况的改善（在跑步机测试中评估）都是这种效果的重要中介（两个变量的P <0.001）。与生活方式干预有关的不良事件包括，在第1年出现的肌肉骨骼症状发生频率略高。结论：体重减轻和健康状况的改善减缓了超重2型糖尿病成年人的运动能力下降。 （由卫生和公共服务部及其他部门资助; ClinicalTrials.gov编号，NCT00017953。）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号