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首页> 外文期刊>Current diabetes reports. >The Diagnosis of Posttransplantation Diabetes Mellitus: Meeting the Challenges
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The Diagnosis of Posttransplantation Diabetes Mellitus: Meeting the Challenges

机译：移植后糖尿病的诊断：迎接挑战

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Posttransplantation diabetes mellitus (PTDM) is a major complication after renal transplantation due to its negative impact on patient and graft survival, and affects up to 40% of renal transplant recipients. The generation of evidence regarding its optimal treatment is now progressing with some emphasis on early postoperative insulin treatment that targets beta-cell failure. This therapy seems to benefit renal transplant patients but contrasts with previous PTDM guidelines that were following treatment of type 2 diabetes mellitus (DM): oral antidiabetics first, insulin last. Similarly, in the current PTDM consensus recommendations, diagnostic procedures are in accordance with the American Diabetes Association (ADA) recommendations for diagnosis of DM. PTDM and type 2DM, however, are distinct disease entities with different pathophysiological backgrounds. This review will discuss the significance of the standard diagnostic criteria for DM in patients after renal transplantation without prior DM. In particular, the role of glycated hemoglobin (HbA1c) and oral glucose tolerance testing (OGTT) will be reviewed. In addition, the potential role of other glycated proteins and continuous glucose monitoring will be covered, although these parameters are not yet part of the consensus recommendations.
机译：移植后糖尿病（PTDM）由于其对患者和移植物存活的负面影响，是肾移植后的主要并发症，并影响多达40％的肾移植受者。关于其最佳治疗方法的证据的开发目前正在取得进展，重点放在针对β细胞衰竭的早期术后胰岛素治疗上。该疗法似乎使肾移植患者受益，但与2型糖尿病（DM）治疗之后的先前PTDM指南形成对比：首先口服降糖药，最后使用胰岛素。同样，在当前的PTDM共识建议中，诊断程序符合美国糖尿病协会（ADA）对DM诊断的建议。然而，PTDM和2DM型是具有不同病理生理背景的独特疾病实体。这篇综述将讨论在没有先天性糖尿病的肾脏移植患者中，糖尿病标准诊断标准的意义。特别是，将对糖化血红蛋白（HbA1c）和口服葡萄糖耐量测试（OGTT）的作用进行综述。此外，尽管这些参数还不是共识建议的一部分，但将涵盖其他糖基化蛋白和连续葡萄糖监测的潜在作用。

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