Relative contribution of DNA repair, cell cycle checkpoints and cell death to survival after DNA damage in Drosophila larvae

Jaklevic BR; Su TT

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Relative contribution of DNA repair, cell cycle checkpoints and cell death to survival after DNA damage in Drosophila larvae

机译：果蝇幼虫DNA损伤后DNA修复，细胞周期检查点和细胞死亡对存活的相对贡献

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Background: Components of the DNA damage checkpoint are essential for surviving exposure to DNA damaging agents. Checkpoint activation leads to cell cycle arrest, DNA repair, and apoptosis in eukaryotes. Cell cycle regulation and DNA repair appear essential for unicellular systems to survive DNA damage. The relative importance of these responses and apoptosis for surviving DNA damage in multicellular organisms remains unclear.

机译：背景：DNA损伤检查站的组件对于幸免于暴露于DNA破坏剂中至关重要。检查点激活导致真核生物的细胞周期停滞，DNA修复和凋亡。细胞周期调节和DNA修复对于单细胞系统幸免于DNA损伤似乎至关重要。这些反应和凋亡对于多细胞生物中幸存的DNA损伤的相对重要性仍然不清楚。

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《Current Biology: CB》 |2004年第1期|共10页
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Jaklevic BR; Su TT;
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正文语种 eng
中图分类生物科学;
关键词
Ataxia-telangiectasia gene; Ionizing-radiation; Saccharomyces-cerevisiae; Midblastula transition; S-phase; Melanogaster; Replication; Atm; Mei-41; Recombination;

机译：共济失调-毛细血管扩张基因;电离辐射;酿酒酵母;中胚层过渡;S期;黑色素瘤;复制;Atm;Mei-41;重组;

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1. Relative contribution of DNA repair, cell cycle checkpoints and cell death to survival after DNA damage in Drosophila larvae [J] . Jaklevic BR, Su TT Current Biology: CB . 2004,第1期

机译：果蝇幼虫DNA损伤后DNA修复，细胞周期检查点和细胞死亡对存活的相对贡献
2. p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells [J] . Mark S. Phong, Robert D. Van Horn, Shuyu Li, Molecular and Cellular Biology . 2010,第15期

机译：p38丝裂原激活的蛋白激酶可促进细胞存活，响应DNA损伤，但对于人类癌细胞中的G2 DNA损伤检查点不是必需的
3. Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage. [J] . Nimbalkar D, Quelle FW Cell cycle . 2008,第18期

机译：磷酸肌醇3激酶信号覆盖了G2期阻滞检查点，并促进了DNA损伤后异常的细胞循环和造血细胞的死亡。
4. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells [C] . Karin N. Kleinhans, Martin D. Burkhalter Else Kro?ner-Fresenius Symposium on the Advances in Stem Cell Aging . 2012

机译：老化干细胞中的DNA损伤，检查点反应和细胞周期控制
5. DNA damage response in Drosophila melanogaster: Orchestrating repair with cell cycle checkpoints. [D] . LaRocque, Jeannine Ruth. 2007

机译：果蝇的DNA损伤反应：用细胞周期检查点协调修复。
6. DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints [O] . Zhongsheng You, Julie M. Bailis -1

机译：DNa损伤和决定：CTIp坐标DNa修复和细胞周期检查点
7. Relative Contribution of DNA Repair, Cell Cycle Checkpoints, and Cell Death to Survival after DNA Damage in Drosophila Larvae [O] . Jaklevic Burnley R., Su Tin Tin 2004

机译：果蝇幼虫DNA损伤后DNA修复，细胞周期检查点和细胞死亡对存活的相对贡献。
8. Studies of DNA Repair in Saccharomyces Cerevisiae. I. Characterization of a New Allele of RAD6. II. Investigation of Events in the First Cell Cycle after DNA Damage [R] . Douthwright-Fasse, J. A. 1979

机译：酿酒酵母中DNa修复的研究。一，RaD6新等位基因的特征。 II。 DNa损伤后第一个细胞周期事件的调查

Relative contribution of DNA repair, cell cycle checkpoints and cell death to survival after DNA damage in Drosophila larvae

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