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首页> 外文期刊>Current Biology: CB >Stem Cell Dynamics in Response to Nutrient Availability
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Stem Cell Dynamics in Response to Nutrient Availability

机译：干细胞动力学对养分可用性的响应

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When nutrient availability becomes limited, animals must actively adjust their metabolism to allocate limited resources and maintain tissue homeostasis [1-3]. However, it is poorly understood how tissues maintained by adult stem cells respond to chronic changes in metabolism. To begin to address this question, we fed flies a diet lacking protein (protein starvation) and assayed both germline and intestinal stem cells. Our results revealed a decrease in stem cell proliferation and a reduction in stem cell number; however, a small pool of active stem cells remained. Upon refeeding, stem cell number increased dramatically, indicating that the remaining stem cells are competent to respond quickly to changes in nutritional status. Stem cell maintenance is critically dependent upon intrinsic and extrinsic factors that act to regulate stem cell behavior [4]. Activation of the insulin/IGF signaling pathway in stem cells and adjacent support cells in the germline was sufficient to suppress stem cell loss during starvation. Therefore, our data indicate that stem cells can directly sense changes in the systemic environment to coordinate their behavior with the nutritional status of the animal, providing a paradigm for maintaining tissue homeostasis under metabolic stress.
机译：当营养物的供应变得有限时，动物必须积极调整其新陈代谢以分配有限的资源并维持组织的动态平衡[1-3]。然而，人们对由成年干细胞维持的组织如何应对新陈代谢的慢性变化知之甚少。为了解决这个问题，我们给果蝇喂食缺乏蛋白质的食物（蛋白质饥饿），并分析了种系和肠道干细胞。我们的结果显示干细胞增殖减少，干细胞数量减少。但是，仍然保留了一小部分活性干细胞。重新喂养后，干细胞数量急剧增加，表明剩余的干细胞有能力对营养状况的变化做出快速反应。干细胞的维持至关重要地依赖于内在和外在因素，这些因素起着调节干细胞行为的作用[4]。种系中干细胞和相邻支持细胞中胰岛素/ IGF信号通路的激活足以抑制饥饿期间的干细胞损失。因此，我们的数据表明，干细胞可以直接感知系统环境的变化，以使其行为与动物的营养状况相协调，从而为在代谢压力下维持组织稳态提供了范例。

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