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首页> 外文期刊>Transplantation Proceedings >What kind of changes occurred in clinical characteristics of deceased kidney donor recipients after national allocation system in Turkey? A single-center retrospective analysis
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What kind of changes occurred in clinical characteristics of deceased kidney donor recipients after national allocation system in Turkey? A single-center retrospective analysis

机译：在土耳其实行国家分配制度后，死者的肾脏捐赠者的临床特征发生了什么样的变化？单中心回顾性分析

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Objective: Clinical characteristics of recipients of deceased donor renal transplantations were evaluated in the period before versus after implmentation of The National Allocation System (NAS). Patients and Methods: We evaluated retrospectively clinical profiles of the 42 after NAS (June 2008-December 2010) versus 42 consecutive deceased donor renal transplantation patients before NAS. Patient and graft survival rates were assessed using the Kaplan-Meier method; graft function was assessed based on creatinine clearance with the Cockcroft Gault equation. Patient and donor data were obtained from medical records. Results: Recipients were older in the pre-NAS group (39 ± 8 vs 33 ± 8 years, respectively; P =.001) and median duration of preoperative dialysis was longer in the post-NAS group (103 ± 61 months vs 50 ± 36 months, respectively; P =.000). The average number of human leukocyte antigen-mismatched antigens were pre-NAS 3.4 ± 1.0 versus post-NAS 3.9 ± 1.2 (P =.05). Considering the recipients serological status 9 were hepatitis C virus (HCV)(+) and 2 hepatitis B virus (HBV)(+) among the post-NAS versus no HBV(+) and only 1 HCV(+) patient pre-NAS. Kaplan-Meier analysis of graft survival rates showed 90% at 1 and 85% at 3 years pre-NAS. Similar to 95% at 1 and 86% at 3 years for the post-NAS group (P >.05). Likewise, patient survival rates for both groups at 1 and 3 years were 97%. The mean parameter of donor age, allograft loss, cold ischemia time, patient death, number of retransplantations, HBV(+) patients, and delayed graft function were similar between groups (P >.05). Discussion: After NAS the transplant recipients were older, had a longer duration of dialysis, greater number of HLA mismatched antigens and, more HCV(+). No differences were observed in short-term patient and graft survival rates.
机译：目的：在实施国家分配系统（NAS）之前和之后评估死者捐赠的肾脏移植的临床特征。患者和方法：我们回顾性评估了42例NAS患者（2008年6月至2010年12月）与42例NAS患者之前连续的死者供肾移植患者的临床资料。使用Kaplan-Meier方法评估患者和移植物的存活率。使用Cockcroft Gault方程基于肌酐清除率评估移植物功能。从医疗记录中获取患者和供体数据。结果：NAS前组的接受者年龄较大（分别为39±8 vs 33±8岁; P = .001），NAS后组的术前透析中位时间更长（103±61个月vs 50±分别为36个月; P = .000）。人类白细胞抗原不匹配抗原的平均数量为NAS前3.4±1.0，而NAS后为3.9±1.2（P = .05）。考虑到接受者的血清学状况，NAS后有9名患者是丙型肝炎病毒（HCV）（+）和2名乙型肝炎病毒（HBV）（+），而无HBV（+）和只有1名HCV（+）NAS前患者。 Kaplan-Meier移植物存活率的分析显示，NAS前1年时移植物存活率为90％，3年时为85％。 NAS后组在1年时为95％，在3年时为86％（P> .05）。同样，两组的1年和3年患者生存率均为97％。组间的供体年龄，同种异体移植物丢失，冷缺血时间，患者死亡，再移植次数，HBV（+）患者和移植物延迟功能的平均参数相似（P> .05）。讨论：NAS后，移植接受者年龄较大，透析时间更长，HLA错配抗原数量更多，HCV（+）数量更多。短期患者和移植物存活率未观察到差异。

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