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首页> 外文期刊>Transplantation Proceedings >Can the kidney weight and recipient body weight ratio predict long-term graft outcome in living donor kidney transplantation?
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Can the kidney weight and recipient body weight ratio predict long-term graft outcome in living donor kidney transplantation?

机译：肾脏重量和受体体重比能否预测活体供体肾脏移植的长期移植结果？

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摘要

We investigated the effect of the donor kidney weight (Kw) to recipient body weight (Rw)ratio (Kw/Rw) on long-term graft function. To investigate the impact of the Kw/Rw ratio on the graft function, we retrospectively collected data from 213 kidney transplant recipients at least 5 years Post- transplantations. Renal function showed a positive correlation with the Kw/Rw ratio until 5 years after transplantation (at 60 months after transplantation, R = 0.158, P =.023); however, this ratio does not affect graft survival (P =.794). We used the mixed-effect model to identify the factors that affect the estimated glomerular filtration rate (eGFR) over time. In univariate analysis, donor age, BSA, kidney weight, and Kw/Rw ratio were associated with eGFR. To identify independent factors that affect to the eGFR, multivariate analysis using a mixed model was applied. Donor age (P <.001) and Kw/Rw ratio (P <.001) were independent factors that affected the eGFR. To identify the cutoff values of the Kw/Rw ratio and donor age that affect long-term graft function, multiple testing using a mixed model was applied. The cutoff value for the Kw/Rw ratio was 3.16 (P =.0104) and the cutoff value of donor age was 44 years (P =.0001). Based on our results, we conclude that the Kw/Rw ratio and donor age are important factors for the long-term function of graft.
机译：我们调查了供体肾脏重量（Kw）与受体体重（Rw）之比（Kw / Rw）对长期移植功能的影响。为了研究Kw / Rw比对移植功能的影响，我们回顾了至少移植5年后从213位肾移植受者中收集的数据。直到移植后5年，肾功能与Kw / Rw比呈正相关（移植后60个月，R = 0.158，P = .023）;但是，该比率不会影响移植物的存活率（P = .794）。我们使用混合效应模型来确定随时间影响估计肾小球滤过率（eGFR）的因素。在单变量分析中，供体年龄，BSA，肾脏重量和Kw / Rw比与eGFR相关。为了确定影响eGFR的独立因素，应用了使用混合模型的多元分析。供体年龄（P <.001）和Kw / Rw比（P <.001）是影响eGFR的独立因素。为了确定影响长期移植功能的Kw / Rw比和供体年龄的临界值，使用了混合模型进行多次测试。 Kw / Rw比的临界值为3.16（P = .0104），供体年龄的临界值为44岁（P = .0001）。根据我们的结果，我们得出结论，Kw / Rw比和供体年龄是影响移植物长期功能的重要因素。

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