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The immunogenicity of pneumococcal polysaccharides in infants and children: A meta-regression

机译：婴幼儿肺炎球菌多糖的免疫原性：Meta回归

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摘要

The immunogenicity of plain (not conjugated) pneumococcal polysaccharides in children and infants was reviewed using a systematic literature search. Immunogenicity was defined as the fold-increase in serotype specific antibody concentration after a single dose of plain polysaccharide vaccine in unprimed subjects. Meta-regression was used to calculate the influence of study treatments including subject age, sampling time, dosage, immunization route, vaccine composition and study location. Immunogenicity increased with age for all serotypes, and the increase was more rapid in the first 11 months of life. Study location was the next most significant study variable, with higher responses in countries with lower GDP. A flat dose-response curve was observed over a range from 5 to 50 mu g polysaccharide. Serotypes 6A, 6B, 14, 19F and 23F were significantly less immunogenic than serotypes 2, 3, 4, 7F, 8, 9N, 9V and 18C in 11 month old children, but continued to increase in immunogenicity with age until reaching similar levels at 6 years. Some proposed T-independent immune mechanisms could explain the differences in serotype immunogenicity
机译：使用系统的文献检索，对儿童和婴儿中的普通（非共轭）肺炎球菌多糖的免疫原性进行了综述。免疫原性定义为在未引发受试者中单剂普通多糖疫苗后血清型特异性抗体浓度的增加倍数。使用元回归来计算研究治疗的影响，包括受试者年龄，采样时间，剂量，免疫途径，疫苗组成和研究地点。所有血清型的免疫原性都随着年龄的增长而增加，并且在生命的头11个月中，这种增长更为迅速。研究地点是下一个最重要的研究变量，在GDP较低的国家中，回答较高。在5至50μg多糖的范围内观察到平坦的剂量反应曲线。在11个月大的儿童中，血清型6A，6B，14、19F和23F的免疫原性明显低于血清型2、3、4、7F，8、9N，9V和18C，但随着年龄的增长，免疫原性继续增加，直至达到相同水平。 6年一些提议的非T依赖性免疫机制可以解释血清型免疫原性的差异

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