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首页> 外文期刊>Vaccine >Immunogenicity of pneumococcal conjugate vaccines in infants after two or three primary vaccinations: a systematic review and meta-analysis.
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Immunogenicity of pneumococcal conjugate vaccines in infants after two or three primary vaccinations: a systematic review and meta-analysis.

机译：两次或三次初次接种疫苗后婴儿肺炎球菌结合疫苗的免疫原性：系统评价和荟萃分析。

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Pneumococcal conjugate vaccines have been successfully used in infant vaccination programs. While most countries have used vaccination schedules with three primary immunisations and one booster dose, some countries have implemented schedules with only two primary immunisations and a booster dose. This systematic review aims to summarize evidence on immunogenicity of pneumococcal conjugate vaccines in infants comparing two and three primary immunisations before a booster dose is given. We systematically reviewed papers published between 1999 and 2011. Results from individual studies were pooled in a meta-analysis with the difference in proportion of children achieving serotype-specific ELISA antibody levels of >=0.35 micro g/ml. We estimated that about 10% less children achieve ELISA antibody levels of >=0.35 micro g/ml after two primary immunisations compared to three primary immunisations for most of serotypes included in one of the licensed pneumococcal conjugate vaccines. This difference in proportion was higher for serotypes 6B and 23F, where -49.4% (-66.0; -32.9%) and -26.9% (-37.2%; -16.6%) less children achieved protective antibody levels. These results support the notion that the majority of children are protected by two primary immunisations with pneumococcal conjugate vaccines in the first year of life. However, for serotypes 6B and 23F protection may be reduced.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2011.09.011
机译：肺炎球菌结合疫苗已成功用于婴儿疫苗接种计划。尽管大多数国家/地区使用了三项初次免疫和一剂加强剂量的疫苗接种时间表，但一些国家/地区却只实施了两次初次免疫和一剂加强剂量的疫苗接种时间表。这项系统的综述旨在总结有关婴儿肺炎球菌结合疫苗的免疫原性的证据，比较给予加强剂量之前的两次和三次初次免疫。我们系统地回顾了1999年至2011年之间发表的论文。在荟萃分析中汇总了各个研究的结果，达到血清型特异性ELISA抗体水平> = 0.35 micro g / ml的儿童比例差异。我们估计，与一次许可的肺炎球菌结合疫苗中所含大多数血清型的三个初次免疫相比，两次初次免疫后获得ELISA抗体水平> = 0.35 micro g / ml的儿童约少10％。对于血清型6B和23F，这种比例差异更高，其中达到保护性抗体水平的儿童减少了-49.4％（-66.0; -32.9％）和-26.9％（-37.2％; -16.6％）。这些结果支持这样的观点，即大多数儿童在生命的第一年受到两次肺炎球菌结合疫苗的初次免疫的保护。但是，对于血清型6B和23F，可能会减少保护。数字对象标识符http://dx.doi.org/10.1016/j.vaccine.2011.09.011

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