Mycobacterium bovis (Bacille Calmette-Guerin) bacteremia in immunocompetent neonates following vaccination

Thamthitiwat Somsak; Marin Nongnush; Baggett Henry C.; Peruski Leonard F.; Kiatkulwiwat Wannachai; Panumatrasmee Veerachai; Varma Jay K.; Nateniyom Sriprapa; Akarasewi Pasakorn; Maloney Susan A. .

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Mycobacterium bovis (Bacille Calmette-Guerin) bacteremia in immunocompetent neonates following vaccination

机译：免疫后新生儿中的牛分枝杆菌（Bacille Calmette-Guerin）菌血症

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We describe four cases of Mycobacterium tuberculosis complex bacteremia diagnosed in immunocompetent neonates, who presented with high fever and/or jaundice within 72 h after Bacille Calmette-Guerin (BCG) vaccination. All neonates were hospitalized, and none received anti-mycobacterial therapy. All recovered completely and remain healthy 2-3.5 years later. Genotyping of one available isolate identified the pathogen as Mycobacterium bovis BCG. The similar clinical presentations and close temporal association between BCG vaccination and illness suggest that all four neonates likely had BCG bacteremia. BCG bacteremia shortly following vaccination among healthy neonates has not been previously described and merits further study to determine its frequency and clinical significance. Published by Elsevier Ltd.

机译：我们描述了4例在免疫能力强的新生儿中诊断出的结核分枝杆菌复杂菌血症，这些新生儿在接种Bacille Calmette-Guerin（BCG）后72小时内出现高烧和/或黄疸。所有新生儿均入院，均未接受抗分枝杆菌治疗。所有这些都可以完全恢复并在2-3.5年后保持健康。对一种可用分离株的基因分型将病原体鉴定为牛分枝杆菌BCG。 BCG疫苗接种与疾病之间相似的临床表现和紧密的时间关联性表明，所有四个新生儿都可能患有BCG菌血症。此前尚未对健康新生儿进行疫苗接种后的BCG菌血症进行过描述，值得进一步研究以确定其发生频率和临床意义。由Elsevier Ltd.发布

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《Vaccine》 |2011年第9期|共4页
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Thamthitiwat Somsak; Marin Nongnush; Baggett Henry C.; Peruski Leonard F.; Kiatkulwiwat Wannachai; Panumatrasmee Veerachai; Varma Jay K.; Nateniyom Sriprapa; Akarasewi Pasakorn; Maloney Susan A. .;
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正文语种 eng
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Bacille Calmette-Guerin vaccine: BCG; immunologic-drug; immunostimulant-drug; vaccine; adverse effec; genotyping; immunocompetence;

机译：Bacille Calmette-Guerin疫苗：卡介苗;免疫药物;免疫刺激药物;疫苗;不良反应;基因分型;免疫能力;

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1. Mycobacterium bovis (Bacille Calmette-Guerin) bacteremia in immunocompetent neonates following vaccination [J] . Thamthitiwat Somsak, Marin Nongnush, Baggett Henry C., Vaccine . 2011,第9期

机译：免疫后新生儿中的牛分枝杆菌（Bacille Calmette-Guerin）菌血症
2. Adverse reactions to Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccination against tuberculosis in humans, veterinary animals and wildlife species. [J] . Murphy D, Corner LA, Gormley E Tuberculosis . 2008,第4期

机译：牛分枝杆菌杆菌卡介苗（BCG）疫苗接种对人类，兽医和野生动植物的结核病产生不良反应。
3. Efficacy of oral and parenteral routes of mycobacterium bovis bacille Calmette-Guerin vaccination against experimental bovine tuberculosis in white-tailed deer (Odocoileus virginianus): a feasibility study. [J] . Nol P, Palmer MV, Waters WR, Journal of wildlife diseases . 2008,第2期

机译：牛分枝杆菌杆菌卡介苗的口服和非肠道途径对白尾鹿（Odocoileus virginianus）的实验性牛结核病疫苗接种的有效性：一项可行性研究。
4. Isolated Strains of Nontuberculous Mycobacterium Interfere with Immune Responses Associated with Mycobacterium bovis BCG Vaccination [C] . Chunfang Wang, Huarui Qi, Xiuyun Jiang International Conference on Biotechnology, Chemical and Materials Engineering . 2014

机译：孤立的非萎缩分枝杆菌的菌株干扰与肉杆菌BCG疫苗接种的免疫应答
5. Vaccination of white-tailed deer with Mycobacterium bovis bacille Calmette-Guerin: Efficacy, immunology, and molecular detection. [D] . Nol, Pauline. 2010

机译：用牛分枝杆菌杆菌Calmette-Guerin对白尾鹿进行疫苗接种：功效，免疫学和分子检测。
6. Fecal Volatile Organic Ccompound Profiles from White-Tailed Deer (Odocoileus virginianus) as Indicators of Mycobacterium bovis Exposure or Mycobacterium bovis Bacille Calmette-Guerin (BCG) Vaccination [O] . Randal S. Stahl, Christine K. Ellis, Pauline Nol, -1

机译：来自白尾鹿（Odocoileus virginianus）的粪便挥发性有机化合物概况作为牛分枝杆菌暴露或牛分枝杆菌芽孢杆菌卡介苗（BCG）疫苗接种的指标
7. Fecal Volatile Organic Ccompound Profiles from White-Tailed Deer (Odocoileus virginianus) as Indicators of Mycobacterium bovis Exposure or Mycobacterium bovis Bacille Calmette-Guerin (BCG) Vaccination. [O] . Randal S Stahl, Christine K Ellis, Pauline Nol, 2015

机译：来自白尾鹿（Odocoileus virginianus）的粪便挥发性有机化合物概况作为牛分枝杆菌暴露或牛分枝杆菌Bacille Calmette-Guerin（BCG）疫苗接种的指示剂。

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Mycobacterium bovis (Bacille Calmette-Guerin) bacteremia in immunocompetent neonates following vaccination

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