Pneumococcal vaccines in adults: Assessing the evolving evidence

Grabenstein John D.; Manoff Susan B.

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Pneumococcal vaccines in adults: Assessing the evolving evidence

机译：成人肺炎球菌疫苗：评估不断发展的证据

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Pneumococcal polysaccharide vaccines (PPSVs) are a public-health success. Before their widespread use, people at increased risk for pneumococcal disease (e.g., some with advanced age, sickle-cell disease, or asplenia) developed fulminant pneumococcal sepsis, which was often fatal. PPSV vaccination reduces morbidity and associated mortality [1], [0010] , [3], [4] and [0025] . Pneumococcal conjugate vaccines (PCVs) are another public-health success. PCVs provide substantial direct benefits to infants and young children, and help indirectly to reduce pneumococcal disease among adults [6].

机译：肺炎球菌多糖疫苗（PPSV）是公共卫生领域的成功之举。在广泛使用之前，肺炎球菌疾病风险较高的人（例如，某些年龄较大，镰状细胞病或无精子症）发展为暴发性肺炎球菌败血症，这通常是致命的。 PPSV疫苗接种可降低发病率和相关死亡率[1]，[0010]，[3]，[4]和[0025]。肺炎球菌结合疫苗（PCV）是另一项公共卫生方面的成功。 PCV为婴幼儿提供了实质性的直接好处，并间接帮助减少了成年人中的肺炎球菌疾病[6]。

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《Vaccine》 |2011年第37期|共6页
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Grabenstein John D.; Manoff Susan B.;
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immunoglobulin G: IgG; 23-valent pneumococcal polysaccharide vaccine: PPSV23; immunologic-drug; immunostimulant-drug; vacci; seven-valent pneumococcal conjugate vaccine: PCV7; immunologic-drug; immunostimulant-drug; vaccine; tetravalent meningococcal conjugate vaccine: MCV4; immunologic-drug; immunostimulant-drug; clinical; drug regimen; decision making; immune competence; therapy response; memory response; disease morbidity; nasopharyngeal colonization; opsonophagocytic activity; intellectual content; Alaskan guideline; hyperesponsiveness impact;

机译：免疫球蛋白G：IgG;23价肺炎球菌多糖疫苗：PPSV23;免疫药;免疫刺激药物;vacci;七价肺炎球菌结合疫苗：PCV7;免疫药;免疫刺激药;疫苗;疫苗;四价脑膜炎球菌结合疫苗：MCV4;免疫药物;免疫刺激药物;临床;药物治疗方案;决策;免疫能力;治疗反应;记忆反应;疾病发病率;鼻咽部定植;调理吞噬活动;智力含量;阿拉斯加指南;过敏反应影响;

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专利

1. Pneumococcal vaccines in adults: Assessing the evolving evidence [J] . Grabenstein John D., Manoff Susan B. Vaccine . 2011,第37期

机译：成人肺炎球菌疫苗：评估不断发展的证据
2. Comparison of an opsonophagocytic assay and IgG ELISA to assess responses to pneumococcal polysaccharide and pneumococcal conjugate vaccines in children and young adults with sickle cell disease. [J] . Vernacchio L, Romero Steiner-S, Martinez JE, The Journal of Infectious Diseases . 2000,第3期

机译：调理吞噬试验和IgG ELISA的比较，以评估镰刀状细胞病儿童和年轻人对肺炎球菌多糖和肺炎球菌结合疫苗的反应。
3. Assessing the potential cost effectiveness of pneumococcal vaccines in the US: methodological issues and current evidence. [J] . Hutton J, Iglesias C, Jefferson TO Drugs and aging . 1999,第Suppla1期

机译：评估美国肺炎球菌疫苗的潜在成本效益：方法论问题和现有证据。
4. Pneumococcal proteins that may constitute the next generation vaccine for pneumococcal disease [C] . David E. Briles, Susan K. Hollingshead, Marilyn J. Crain, International Symposium on Tonsils and Mucosal Barriers of Upper Airways . 2003

机译：肺炎球菌蛋白，可构成肺炎球菌病的下一代疫苗
5. Immune responses of pneumococcal polysaccharide and conjugate vaccines in adults: Effect of human immunodeficiency virus infection [D] . Ahmed, Faruque 1995

机译：成人肺炎球菌多糖和结合疫苗的免疫应答：人类免疫缺陷病毒感染的影响
6. Disease Burden and Etiologic Distribution of Community-Acquired Pneumonia in Adults: Evolving Epidemiology in the Era of Pneumococcal Conjugate Vaccines [O] . Jung Yeon Heo, Joon Young Song 2018

机译：成人社区获得性肺炎的疾病负担和病因分布：肺炎球菌结合疫苗时代流行病学的发展
7. PIN64 Assessing the Cost-Effectiveness (CE) of Vaccinating the Elderly and at-Risk Adults With the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) Compared to the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) or no Vaccination (NoVac) in the UK [O] . Y. Jiang, A. Gauthier, S.T. Keeping, 2012

机译：与英国13价肺炎球菌缀合物疫苗（PCV13）或英国没有疫苗（Novac）相比，评估疫苗的成本效果（CE）与23价肺炎球菌多糖疫苗（PPV23）疫苗接种的成本效果（CE）

Pneumococcal vaccines in adults: Assessing the evolving evidence

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