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首页> 外文期刊>Vaccine >Recurrent apnoea post immunisation: Informing re-immunisation policy
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Recurrent apnoea post immunisation: Informing re-immunisation policy

机译：免疫后复发性呼吸暂停：告知再次免疫政策

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Background: Preterm infants should receive immunisations according to their chronological, rather than gestational, age however concern about possible adverse events following immunisation (AEFI) in this group often means routine immunisations are delayed. A small number of infants may have apnoea with or without bradycardia temporally associated with immunisation. The risk factors for, and recurrence rate of apnoea with subsequent immunisations are unknown, which makes planning for subsequent immunisations for these highly vulnerable infants difficult.Aim: To determine recurrence rates for apnoea temporally associated with immunisation in preterm and term infants and to explore potential risk factors associated with recurrent apnoea in preterm infants.Method: A retrospective analysis of all apnoea +/-bradycardia AEFIs in preterm and term infants, reported to the Surveillance of Adverse Events Following Vaccination In the Community (SAEFVIC), Victoria, Australia over a 3-year period from May 2007 to April 2010. Apnoea +/-bradycardia was defined as temporally associated with immunisation if it occurred up to 48 h after immunisation.Results: 7 out of 38 [18%, 95% confidence interval 6-31%] preterm infants with apnoea +/-bradycardia post initial immunisation had recurrent apnoea with subsequent immunisations. Possible risk factors for recurrence included: lower birth weight (p = 0.04) and ongoing hospitalisation for complications relating to prematurity (p = 0.01). No preterm infant with recurrent apnoea had a third episode of apnoea with subsequent immunisation. None of the 8 term infants with a reported apnoea AEFI had recurrence of apnoea with subsequent immunisation.Conclusion: There is a risk of recurrence of apnoea associated with immunisation in preterm infants. We recommend that preterm infants with apnoea post immunisation should receive reliable cardiorespiratory monitoring for a minimum of 24 h following the next scheduled immunisation
机译：背景：早产儿应根据其时间顺序而不是妊娠年龄进行免疫接种，但是，由于担心该组免疫接种后可能发生的不良事件（AEFI），这通常意味着常规免疫接种被推迟了。少数婴儿可能在暂时性与免疫相关的心动过缓或无呼吸暂停的情况下出现呼吸暂停。目的在于确定早产和足月婴儿在时间上与免疫相关的呼吸暂停复发率，并探索潜在的呼吸道呼吸暂停再接种的危险因素和复发率，这是未知的。方法：对早产和足月婴儿中所有呼吸暂停+/-心动过缓AEFI进行回顾性分析，报告给澳大利亚维多利亚州社区（SAEFVIC）接种疫苗后的不良事件监测从2007年5月到2010年4月的3年期间。如果在免疫后48小时内发生呼吸暂停+/-心动过缓，则在时间上与免疫相关。结果：38分之7 [18％，95％置信区间6-31 [％]初次免疫后出现呼吸暂停+/-心动过缓的早产儿在再次免疫后出现了反复呼吸暂停。复发的可能危险因素包括：较低的出生体重（p = 0.04）和因早产并发症而继续住院治疗（p = 0.01）。没有复发性呼吸暂停的早产儿没有第三次呼吸暂停并随后进行了免疫接种。 AEFI报告为呼吸暂停的8个足月婴儿中没有一个在随后的免疫接种后复发。结论：早产儿存在与免疫相关的呼吸暂停复发的风险。我们建议在下一次计划免疫后至少24小时内接受可靠的心肺监护，进行免疫后呼吸暂停的早产儿

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