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首页> 外文期刊>Vaccine >Enlarging the 'Audacious Goal': Elimination of the world's high prevalence neglected tropical diseases
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Enlarging the 'Audacious Goal': Elimination of the world's high prevalence neglected tropical diseases

机译：扩大“大胆目标”：消除世界上高流行率被忽视的热带病

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The high prevalence neglected tropical diseases (NTDs) exhibit a global disease burden that exceeds malaria, tuberculosis, and other better known global health conditions; they also represent a potent force in trapping the world's poorest people in poverty. Through extremely low cost national programs of disease mapping and mass drug administration (MDA) for the seven most common NTDs, integrated NTD control and elimination efforts are now in place in more than 14 countries through the support of theUnited States Agency for International Development (USAID), the British Department for International Development (DFID), and the Global Network for NTDs and its partners. The World Health Organization (WHO) estimates that in 2008 some 670 million peoplein 75 countries received NTD treatments through these and other sponsored programs. With continued successes the next decade could witness the global elimination of blinding trachoma, human Africa trypanosomiasis (HAT), lymphatic filariasis (LF), onchocerciasis, trachoma, and leprosy as public health problems, in addition to the eradication of dracunculiasis. For other high prevalence NTDs, including hookworm infection, schistosomiasis, Chagas disease and leishmaniasis, new drugs and vaccines may stillbe required. Increasingly it is recognized that the high prevalence NTDs exhibit extensive geographic overlap and polyparasitism is commonly found throughout the world's low income countries. Therefore, global elimination will also require integrated packages of drugs together with vaccine-linked chemotherapy. Ultimately, the global elimination of the high prevalence NTDs will require continued large-scale support from the U.S. Government and selected European governments, however, the emerging marketeconomies, such as Brazil, China, India, Mexico, and Nigeria, and wealthy countries in the Middle East will also have to substantially contribute.
机译：被高度流行的被忽视的热带病（NTD）造成的全球疾病负担超过了疟疾，结核病和其他众所周知的全球健康状况;它们还代表了将世界上最贫穷的人困在贫困中的强大力量。通过针对七个最常见NTD的极低成本的国家疾病测绘和大规模药物管理国家计划，在美国国际开发署（USAID）的支持下，现已在14个以上的国家实施了NTD的综合控制和消除工作），英国国际发展部（DFID）以及NTD及其合作伙伴的全球网络。世界卫生组织（WHO）估计，2008年，在75个国家/地区中，约有6.7亿人通过这些计划和其他赞助计划获得了NTD治疗。随着持续的成功，下一个十年可能见证了除了消灭麦地那龙线虫病之外，全球消除了致盲性沙眼，人类非洲锥虫病（HAT），淋巴丝虫病（LF），盘尾丝虫病，沙眼和麻风病等公共卫生问题。对于其他流行率高的NTD，包括钩虫感染，血吸虫病，恰加斯病和利什曼病，仍可能需要新药和疫苗。越来越多的人认识到，高患病率的非传染性疾病具有广泛的地理重叠，多寄生性寄生虫病在全世界低收入国家中普遍存在。因此，全球淘汰还需要将药物与疫苗相关的化学疗法结合在一起。最终，要在全球范围内消除高发病率NTD，需要美国政府和部分欧洲政府的持续大力支持，但是，新兴市场经济体，例如巴西，中国，印度，墨西哥和尼日利亚，以及巴西的富裕国家中东也将必须作出重大贡献。

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