...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients
【24h】

The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients

机译：血液透析患者中​​金黄色葡萄球菌疫苗的潜在经济价值

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Staphylococcus aureus infections are a substantial problem for hemodialysis patients. Several vaccine candidates are currently under development, with hemodialysis patients being one possible target population. To determine the potential economic value of an S. aureus vaccine among hemodialysis patients, we developed a Markov decision analytic computer simulation model. When S. aureus colonization prevalence was 1%, the incremental cost-effectiveness ratio (ICER) of vaccination was <=$25,217/quality-adjusted life year (QALY). Vaccination became more cost-effective as colonization prevalence, vaccine efficacy, or vaccine protection duration increased or vaccine cost decreased. Even at 10% colonization prevalence, a 25% efficacious vaccine costing $100 prevented 29 infections, 21 infection-related hospitalizations, and 9 inpatient deaths per 1000 vaccinated HD patients. Our results suggest that an S. aureus vaccine would be cost-effective (i.e., ICERs <= $50,000/QALY) among hemodialysis patients over a wide range of S. aureus prevalence, vaccine costs and efficacies, and vaccine protection durations and delineate potential target parameters for such a vaccine. (C) 2012 Elsevier Ltd. All rights reserved.
机译：金黄色葡萄球菌感染是血液透析患者的实质性问题。目前正在开发几种候选疫苗，其中血液透析患者可能是一种目标人群。为了确定血液透析患者中​​金黄色葡萄球菌疫苗的潜在经济价值，我们开发了马尔可夫决策分析计算机仿真模型。当金黄色葡萄球菌定植率为1％时，接种疫苗的成本效益比（ICER）≤25,217美元/质量调整生命年（QALY）。随着定殖率，疫苗效力或疫苗保护期的增加或疫苗成本的降低，疫苗接种变得更具成本效益。即使在10％的定植流行率下，每100例接受免疫接种的HD患者，花费100美元的25％有效疫苗仍可预防29例感染，21例与感染相关的住院以及9例住院死亡。我们的结果表明，在广泛的金黄色葡萄球菌流行率，疫苗成本和功效，疫苗保护期和确定潜在目标范围内的血液透析患者中​​，金黄色葡萄球菌疫苗将具有成本效益（即，ICER <= $ 50,000 / QALY）这种疫苗的参数。 （C）2012 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号