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首页> 外文期刊>Vaccine >Risk of rheumatoid arthritis following vaccination with tetanus, influenza and hepatitis B vaccines among persons 15-59 years of age
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Risk of rheumatoid arthritis following vaccination with tetanus, influenza and hepatitis B vaccines among persons 15-59 years of age

机译：在15-59岁的人群中接种破伤风，流感和乙型肝炎疫苗后发生类风湿关节炎的风险

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Background: Associations between vaccinations, particularly hepatitis B, and onset of rheumatoid arthritis (RA) have been reported, but examined in few large-scale studies.Method: Onset of RA cases and dates of vaccination against hepatitis B, tetanus, and influenza were identified in a retrospective chart review of approximately 1 million Kaiser Permanente Northern California members ages 15-59 years from 1997 through 1999. In a cohort analysis, rates of new-onset RA were compared between vaccinated and unvaccinated within 90, 180, and 365 days. In a case-control analysis, rates of vaccination during exposure intervals (90, 180, 365, and 730 days) were compared between cases and controls using conditional logistic regression.Results: 378 RA cases were included in the cohort analysis; 37 additional cases were included in the case-control analysis. In the cohort analysis the relative risks of RA onset within 90, 180, or 365 days of hepatitis B vaccination were not significant (R.R. = 1.44, p = 0.53; R.R. = 1.67, p = 0.22; R.R. = 1.23, p = 0.59 respectively). We found a possible association between RA and influenza vaccine in the previous 180 and 365 days in the cohort analysis (R.R = 1.36, p = 0.03; R.R. = 1.34, p = 0.01 respectively), but in the case-control analysis, cases were no more likely than controls to have received any of the three vaccines.Conclusions: In this large retrospective study we found no statistically significant association between exposure to hepatitis B vaccine and onset of RA. A possible association between RA and influenza vaccination in the cohort study was not borne out in the larger case-control analysis
机译：背景：已有报道，特别是乙型肝炎疫苗接种与类风湿关节炎（RA）的发病之间有相关性，但在少数大规模研究中得到了研究。方法：RA病例的发病以及接种乙型肝炎，破伤风和流感的日期在一项回顾性图表回顾中确定，从1997年到1999年，大约有100万年龄在15-59岁的北加州凯撒永久居民。在队列分析中，比较了90、180和365天内接种疫苗和未接种疫苗的新发RA发生率。在病例对照分析中，使用条件逻辑回归比较了暴露时间间隔（90、180、365和730天）之间的疫苗接种率。结果：该队列分析包括378名RA病例;病例对照分析中还包括37个病例。在队列分析中，乙型肝炎疫苗接种90、180或365天内RA发作的相对风险不显着（RR分别为1.44，p = 0.53，RR = 1.67，p = 0.22，RR = 1.23，p = 0.59 ）。在队列分析的前180天和365天，我们发现RA和流感疫苗之间可能存在关联（RR分别为1.36，p = 0.03，RR = 1.34，p = 0.01），但在病例对照分析中，病例为结论：在这项大型的回顾性研究中，我们发现暴露于乙型肝炎疫苗与RA发病之间无统计学意义的关联。在较大的病例对照分析中并未证实队列研究中RA与流感疫苗接种之间可能存在关联

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