• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups.
【24h】

An experimental outer membrane vesicle vaccine from N. meningitidis serogroup B strains that induces serum bactericidal activity to multiple serogroups.

机译：来自N的实验性外膜囊泡疫苗。脑膜炎B血清群菌株可诱导血清对多个血清群的杀菌活性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A trivalent native outer membrane vesicle vaccine that has potential to provide broad based protection against Neisseria meningitidis serogroup B strains has been developed. Preliminary immunogenicity studies in mice showed that the vaccine was capable of inducing an effective broad based bactericidal antibody response against N. meningitidis serogroup B strains. These findings in mice have been repeated with a cGMP trivalent NOMV vaccine and extended to show that the bactericidal antibody response induced by the vaccine in mice is effective against strains belonging to serogroups C, Y, W135, X, and NadA-expressing serogroup A strains. Taken together these results suggest that this experimental vaccine may provide protection against both serogroup B and non-serogroup B N. meningitidis strains.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2011.07.124
机译：已经开发了一种三价天然外膜囊泡疫苗，该疫苗有潜力提供针对脑膜炎奈瑟氏球菌B血清群菌株的广泛基础的保护。小鼠的初步免疫原性研究表明，该疫苗能够诱导针对N的有效的广谱杀菌抗体反应。脑膜炎B血清群菌株。已经使用cGMP三价NOMV疫苗重复了这些在小鼠中的发现，并扩展到显示该疫苗在小鼠中诱导的杀菌抗体反应对属于血清群C，Y，W135，X和表达NadA的血清群A菌株有效。 。这些结果加在一起表明该实验疫苗可提供针对血清群B和非血清群B N的保护。脑膜炎菌株。数字对象标识符http://dx.doi.org/10.1016/j.vaccine.2011.07.124

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号