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首页> 外文期刊>Vaccine >Mumps outbreak among vaccinated university students associated with a large party, the Netherlands, 2010.
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Mumps outbreak among vaccinated university students associated with a large party, the Netherlands, 2010.

机译：2010年，与大型派对相关的接种疫苗的大学生中的腮腺炎暴发。

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We investigated a mumps outbreak within a highly vaccinated university student population in the Netherlands by conducting a retrospective cohort study among members of university societies in Delft, Leiden and Utrecht. We used an online questionnaire asking for demographic information, potential behavioural risk factors for mumps and the occurrence of mumps. Vaccine status from the national vaccination register was used. Overall, 989 students participated (20% response rate). Registered vaccination status was available for 776 individuals, of whom 760 (98%) had been vaccinated at least once and 729 (94%) at least twice. The mumps attack rate (AR) was 13.2% (95%CI 11.1-15.5%). Attending a large student party, being unvaccinated and living with more than 15 housemates were independently associated with mumps ((RR 42 (95%CI 10.1-172.4); 3.1 (95%CI 1.7-5.6) and 1.8 (95%CI 1.1-3.1)), respectively). The adjusted VE estimate for two doses of MMR was 68% (95%CI 41-82%). We did not identify additional risk factors for mumps among party attendees. The most likely cause of this outbreak was intense social mixing during the party and the dense communal living environment of the students. High coverage of MMR vaccination in childhood did not prevent an outbreak of mumps in this student population.
机译：我们通过在代尔夫特，莱顿和乌得勒支的大学社团成员之间进行回顾性队列研究，调查了荷兰高度接种疫苗的大学生中的腮腺炎暴发。我们使用了在线调查表，询问人口统计信息，腮腺炎的潜在行为危险因素和腮腺炎的发生。使用了国家疫苗接种登记簿中的疫苗状态。总体而言，有989名学生参加了会议（20％的回应率）。已登记的疫苗接种状态可用于776人，其中760（98％）至少已接种一次，729（94％）至少已接种两次。腮腺炎发作率（AR）为13.2％（95％CI 11.1-15.5％）。参加大型学生聚会，未接种疫苗并且与15名以上室友生活在一起独立于腮腺炎（（RR 42（95％CI 10.1-172.4）; 3.1（95％CI 1.7-5.6）和1.8（95％CI 1.1- 3.1））。两剂MMR的调整后VE估算值为68％（95％CI 41-82％）。我们没有发现聚会参与者腮腺炎的其他危险因素。造成这种疾病爆发的最可能原因是聚会期间的社会交融以及学生密集的社区生活环境。儿童期MMR疫苗的高覆盖率并不能阻止该学生人群中流行性腮腺炎的爆发。

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