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首页> 外文期刊>Vaccine >Kinetics of maternally acquired anti-hepatitis A antibodies: prediction of waning based on maternal or cord blood antibody levels.
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Kinetics of maternally acquired anti-hepatitis A antibodies: prediction of waning based on maternal or cord blood antibody levels.

机译：孕产妇获得的抗A型肝炎抗体的动力学：根据孕产妇或脐带血抗体水平的预测而减弱。

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Background: Timing is critical for efficient hepatitis A vaccination in high endemic areas as high levels of maternal IgG antibodies against the hepatitis A virus (HAV) present in the first year of life may impede the vaccine response. Objectives: To describe the kinetics of the decline of anti-HAV maternal antibodies, and to estimate the time of complete loss of maternal antibodies in infants in Leon, Nicaragua, a region in which almost all mothers are anti-HAV seropositive. Methods: We collected cord blood samples from 99 healthy newborns together with 49 corresponding maternal blood samples, as well as further blood samples at 2 and 7 months of age. Anti-HAV IgG antibody levels were measured by enzyme immunoassay (EIA). We predicted the time when antibodies would fall below 10 mIU/ml, the presumed lowest level of seroprotection. Results: Seroprevalence was 100% at birth (GMC 8392 mIU/ml); maternal and cord blood antibody concentrations were similar. The maternal antibody levels of the infants decreased exponentially with age and the half-life of the maternal antibody was estimated to be 40 days. The relationship between the antibody concentration at birth and time until full waning was described as: critical age (months)=3.355+1.969 * log 10 (Ab-level at birth). The survival model estimated that loss of passive immunity will have occurred in 95% of infants by the age of 13.2 months. Conclusions: Complete waning of maternal anti-HAV antibodies may take until early in the second year of life. The here-derived formula relating maternal or cord blood antibody concentrations to the age at which passive immunity is lost may be used to determine the optimal age of childhood HAV vaccination.
机译：背景：对于在高流行地区进行有效的甲型肝炎疫苗接种而言，时机至关重要，因为出生后第一年出现的高水平抗甲型肝炎病毒（HAV）的孕妇IgG抗体可能会阻碍疫苗的反应。目的：描述尼古拉瓜莱昂（Leon）尼加拉瓜（该地区几乎所有母亲都具有抗HAV血清阳性反应的地区）婴儿中抗HAV母源抗体下降的动力学，并估算其母体抗体完全丧失的时间。方法：我们收集了99例健康新生儿的脐带血样本，以及49例相应的孕妇血样，以及2个月和7个月大的其他血液样本。抗HAV IgG抗体水平通过酶免疫法（EIA）测量。我们预测了抗体降至低于10 mIU / ml（即血清保护的最低水平）的时间。结果：出生时血清阳性率为100％（GMC 8392 mIU / ml）;母体和脐带血抗体浓度相似。婴儿的母体抗体水平随年龄呈指数下降，母体抗体的半衰期估计为40天。出生时抗体浓度与直至完全消失的时间之间的关系描述为：临界年龄（月）= 3.355 + 1.969 * log 10（出生时抗体水平）。生存模型估计，到13.2个月大时，95％的婴儿将发生被动免疫丧失。结论：母体抗HAV抗体的完全减弱可能要持续到生命的第二年年初。将母体或脐带血抗体浓度与被动免疫力丧失年龄联系起来的公式可用于确定儿童HAV疫苗接种的最佳年龄。

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