Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: Homologous or heterologous booster response following two dose or single dose priming

van der Velden Maikel V. W.; Aichinger Gerald; Poellabauer Eva Maria; Loew-Baselli Alexandra; Fritsch Sandor; Benamara Karima; Kistner Otfried; Mueller Markus; Zeitlinger Markus; Kollaritsch Herwig; Vesikari Timo; Ehrlich Hartmut J.; Barrett P. Noel

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Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: Homologous or heterologous booster response following two dose or single dose priming

机译：细胞培养（Vero细胞）衍生的全病毒非佐剂H5N1流感疫苗诱导持久的交叉反应性记忆免疫反应：两次或单次启动后均产生同源或异源加强免疫应答

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Influenza pandemic preparedness involves priming of the population with pre-pandemic vaccines. Such vaccines should be well tolerated and induce a long-lasting immunological memory that can effectively be boosted with a single dose of pandemic vaccine once available. The presented studies assessed different prime-boost regimens with a Vero cell-derived whole virus non-adjuvanted H5N1 vaccine.

机译：流感大流行的预防工作涉及使用大流行前疫苗来启动人群。此类疫苗应具有良好的耐受性，并诱导长期的免疫记忆，一旦可用，可通过单剂量大流行疫苗有效增强这种记忆。提出的研究评估了Vero细胞衍生的全病毒非佐剂H5N1疫苗的不同初免-加强方案。

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《Vaccine》 |2012年第43期|共9页
作者
van der Velden Maikel V. W.; Aichinger Gerald; Poellabauer Eva Maria; Loew-Baselli Alexandra; Fritsch Sandor; Benamara Karima; Kistner Otfried; Mueller Markus; Zeitlinger Markus; Kollaritsch Herwig; Vesikari Timo; Ehrlich Hartmut J.; Barrett P. Noel;
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正文语种 eng
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关键词
H5N1; Pre-pandemic; Influenza; Vero; Whole-virus; Prime-boost;

机译：H5N1;大流行前;流行性感冒;病毒;全病毒;初免;

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1. Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: Homologous or heterologous booster response following two dose or single dose priming [J] . van der Velden Maikel V. W., Aichinger Gerald, Poellabauer Eva Maria, Vaccine . 2012,第43期

机译：细胞培养（Vero细胞）衍生的全病毒非佐剂H5N1流感疫苗诱导持久的交叉反应性记忆免疫反应：两次或单次启动后均产生同源或异源加强免疫应答
2. A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses. [J] . Ehrlich HJ, Muller M, Fritsch S The Journal of Infectious Diseases . 2009,第7期

机译：细胞培养（Vero）衍生的H5N1全病毒疫苗诱导交叉反应记忆反应。
3. A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses [J] . Hartmut J. Ehrlich1 Markus Müller2 Sandor Fritsch1 Markus Zeitlinger2 Greg Berezuk1 Alexandra Löw-Baselli1 Maikel V. W. van der Velden1 Eva Maria Pöllabauer1 Friedrich Maritsch1 Borislava G. Pavlova1 Paul A. Tambyah3 Helen M. L. Oh4 Emanuele Montomoli5 Otfried Kistner1 and P. Noel Barrett1 Journal of Infectious Diseases . 2009,第7期

机译：细胞培养（病毒）衍生的H5N1全病毒疫苗诱导交叉反应性记忆反应
4. Immunologic Mechanism of the Anti-Tumor Immunity Responses Induced by the Altogether Culture Medium of Porcine Cartilage Polysaccharide and S180 Ascites Lump Cells as a Tumor Vaccine [C] . Liu An-jun, Gao Ya, Ma Shan-jie, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：猪软骨多糖和S180腹水肿块细胞作为肿瘤疫苗共同培养基诱导的抗肿瘤免疫反应的免疫学机制
5. The role of monocyte-derived cells in influenza-induced pathology and Th1 immune responses. [D] . Lin, Kaifeng Lisa. 2009

机译：单核细胞衍生细胞在流感诱导的病理学和Th1免疫反应中的作用。
6. A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust Cross-Reactive Immune Response in Adults and the Elderly [O] . Elena Fragapane, Roberto Gasparini, Francesco Schioppa, 2010

机译：异源MF59佐剂的H5N1大流行前流感增强疫苗在成人和老年人中诱导强大交叉反应的免疫反应。
7. A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses. [O] . HARTMUT J. EHRLICH, MARKUS MULLER, SANDOR FRITSCH, 2009

机译：细胞培养（Vero）-Derived H5N1全病毒疫苗诱导交叉反应记忆反应。
8. Immunogenicity of One Dose of Vero Cell Culture-Derived Japanese Encephalitis (JE) Vaccine in Adults Previously Vaccinated with Mouse Brain-Derived JE Vaccine. [R] . Woolpert, T., Staples, J. E., Faix, D. J., 2012

机译：一剂Vero细胞培养衍生的乙型脑炎（JE）疫苗在先前用小鼠脑源性JE疫苗接种的成人中的免疫原性。

Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: Homologous or heterologous booster response following two dose or single dose priming

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