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Human papillomavirus vaccination and Pap testing profile in Manitoba, Canada

机译：加拿大曼尼托巴省的人乳头瘤病毒疫苗接种和巴氏检测

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Background: Females who receive the human papillomavirus (HPV) vaccine may believe they are protected from developing cervical cancer and no longer require screening. Concern has also been expressed that vaccinated females are those that would be screened regularly. This study assesses the Pap testing behavior of vaccinated and non-vaccinated females. Methods: For this population-based retrospective cohort study, vaccination and screening registries were linked for 3540 vaccinated females aged 15 years and over and 9592 matched non-vaccinated females. Conditional logistic regression, the Kaplan-Meier method and Cox regression were used to examine the association between vaccination and Pap testing. Results: Vaccinated females were more likely to have had a Pap test within the year prior to the index date than non-vaccinated females (15-19 years old: OR = 1.38,95% CI 1.20-1.59; 20+ years old: OR = 2.34, 95% CI 1.98-2.76). In the three-year period after the index date, vaccinated females had a significantly higher cumulative probability of having a Pap test (83.3%) than non-vaccinated females (66.1%). Females who had a Pap test within three years prior to the index date were more likely to have a Pap test after the index date (vaccinated: HR = 5.03, 95% CI 4.65-5.45; non-vaccinated HR = 3.97, 95% CI 3.70-4.24). Being vaccinated had a significant effect on Pap testing (15-19 years old: HR = 1.54, 95% CI 1.39-1.69; 20+ years old: HR = 1.87,95% CI 1.52-2.31). 80.1% of vaccinated females who had a Pap test prior to the index date also had one subsequent to it, compared to 70.1% for non-vaccinated females. 41.1% of females had not been vaccinated nor had a Pap test. Conclusion: The majority of vaccinated females continue to participate in screening, and do so at a higher rate than non-vaccinated females. Renewed efforts need to be made to include the large proportion of non-vaccinated, non-screened females in vaccination and/or screening
机译：背景：接种人乳头瘤病毒（HPV）疫苗的女性可能认为自己受到保护免于发展为宫颈癌，因此不再需要筛查。有人还对接种疫苗的女性是应定期筛查的女性表示关注。这项研究评估了接种疫苗和未接种疫苗的女性的巴氏测试行为。方法：在这项基于人群的回顾性队列研究中，对3540名15岁及以上的接种疫苗的女性和9592名配对的未接种疫苗的女性的疫苗接种和筛查登记处进行了链接。使用条件逻辑回归，Kaplan-Meier方法和Cox回归来检验疫苗接种和巴氏检测之间的关联。结果：与未接种疫苗的女性相比，在接种日期之前的一年中，接种疫苗的女性更有可能接受巴氏试验（15-19岁：OR = 1.38,95％CI 1.20-1.59; 20岁以上：OR = 2.34，95％CI 1.98-2.76）。在索引日期后的三年内，接种疫苗的女性进行巴氏试验的累积概率（83.3％）明显高于未接种疫苗的女性（66.1％）。在指标日期之前三年内进行Pap检测的女性更有可能在指标日期之后进行Pap检测（已接种疫苗：HR = 5.03，95％CI 4.65-5.45;未接种HR = 3.97，95％CI 3.70-4.24）。接种疫苗对巴氏检测有显着影响（15-19岁：HR = 1.54，95％CI 1.39-1.69; 20+岁：HR = 1.87,95％CI 1.52-2.31）。在索引日期之前进行子宫颈抹片检查的接种疫苗女性中，有80.1％的女性也进行了子宫颈抹片检查，而未接种疫苗的女性中，女性的这一比例为70.1％。 41.1％的女性未接种疫苗或未进行子宫颈抹片检查。结论：大多数接种疫苗的女性继续参加筛查，并且参与率高于未接种疫苗的女性。需要做出新的努力，使很大一部分未接种疫苗，未接受筛查的女性接受疫苗接种和/或筛查

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