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首页> 外文期刊>Vaccine >Probiotics and colostrum/milk differentially affect neonatal humoral immune responses to oral rotavirus vaccine.
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Probiotics and colostrum/milk differentially affect neonatal humoral immune responses to oral rotavirus vaccine.

机译：益生菌和初乳/牛奶会不同程度地影响新生儿对口服轮状病毒疫苗的体液免疫反应。

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Breast milk (colostrum [col]/milk) components and gut commensals play important roles in neonatal immune maturation, establishment of gut homeostasis and immune responses to enteric pathogens and oral vaccines. We investigated the impact of colonization by probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (Bb12) with/without col/milk (mimicking breast/formula fed infants) on B lymphocyte responses to an attenuated (Att) human rotavirus (HRV) Wa strain vaccine in a neonatal gnotobiotic pig model. Col/milk did not affect probiotic colonization in AttHRV vaccinated pigs. However, unvaccinated pigs fed col/milk shed higher numbers of probiotic bacteria in feces than non-col/milk fed colonized controls. In AttHRV vaccinated pigs, col/milk feeding with probiotic treatment resulted in higher mean serum IgA HRV antibody titers and intestinal IgA antibody secreting cell (ASC) numbers compared to col/milk fed, non-colonized vaccinated pigs. In vaccinated pigs without col/milk, probiotic colonization did not affect IgA HRV antibody titers, but serum IgG HRV antibody titers and gut IgG ASC numbers were lower, suggesting that certain probiotics differentially impact HRV vaccine responses. Our findings suggest that col/milk components (soluble mediators) affect initial probiotic colonization, and together, they modulate neonatal antibody responses to oral AttHRV vaccine in complex ways.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2013.02.020
机译：母乳（初乳[col] /牛奶）成分和肠道功能在新生儿免疫成熟，肠道内稳态的建立以及对肠道病原体和口服疫苗的免疫反应中起重要作用。我们调查了益生菌，鼠李糖乳杆菌GG（LGG）和乳酸双歧杆菌Bb12（Bb12）的定殖对有/无col /牛奶（模仿母乳/配方奶粉喂养的婴儿）的B淋巴细胞对减毒（Att）人轮状病毒（HRV）的反应的影响）在新生的生猪模型中接种WA疫苗。在AttHRV疫苗接种的猪中，Col /牛奶不影响益生菌定植。但是，未接种col / milk的未接种疫苗的猪的粪便中益生菌的数量要高于未接种col / milk的定植对照。在AttHRV疫苗接种的猪中，用益生菌处理的大肠/牛奶喂养的猪相比，非大肠接种的未定殖疫苗的猪，平均血清IgA HRV抗体滴度和肠道IgA抗体分泌细胞（ASC）数更高。在没有col / milk的疫苗接种的猪中，益生菌定植不会影响IgA HRV抗体滴度，但是血清IgG HRV抗体滴度和肠道IgG ASC值较低，表明某些益生菌会差异性地影响HRV疫苗反应。我们的发现表明，col / milk组分（可溶性介质）会影响最初的益生菌定植，并且一起以复杂的方式调节新生儿对口服AttHRV疫苗的抗体反应。数字对象标识符http://dx.doi.org/10.1016/j。疫苗.2013.02.020

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