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首页> 外文期刊>Vaccine >Concomitant administration of GonaCon (TM) and rabies vaccine in female dogs (Canis familiaris) in Mexico
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Concomitant administration of GonaCon (TM) and rabies vaccine in female dogs (Canis familiaris) in Mexico

机译：在墨西哥对雌性犬（犬类犬）同时施用GonaCon（TM）和狂犬病疫苗

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Mexico serves as a global model for advances in rabies prevention and control in dogs. The Mexican Ministry of Health (MMH) annual application of approximately 16 million doses of parenteral rabies vaccine has resulted in significant reductions in canine rabies during the past 20 years. One collateral parameter of rabies programs is dog population management. Enhanced public awareness is critical to reinforce responsible pet ownership. Surgical spaying and neutering remain important to prevent reproduction, but are impractical for achieving dog population management goals. GonaCon (TM), an anti-gonadotropin releasing hormone (GnRH) vaccine, was initially tested in captive female dogs on the Navajo Nation, 2008. The MMH led this international collaborative study on an improved formulation of GonaCon (TM) in captive dogs with local representatives in Hidalgo, Mexico in 2011. This study contained 20 bitches assigned to Group A (6 control), Group B (7 GonaCon (TM)), and Group C (7 GonaCon (TM) and rabies vaccine). Vaccines were delivered IM. Animals were placed under observation and evaluated during the 61-day trial. Clinically, all dogs behaved normally. No limping or prostration was observed, in spite of minor muscle atrophy post-mortem in the left hind leg of dogs that received GonaCon (TM). Two dogs that began the study pregnant give birth to healthy pups. Dogs that received a GonaCon (TM) injection had macro and microscopic lesions consistent with prior findings, but the adverse injection effects were less frequent and lower in intensity. Both vaccines were immunogenic based on significant increases in rabies virus neutralizing antibodies and anti-GnRH antibodies in treatment Groups B and C. Simultaneous administration of GonaCon (TM) and rabies vaccine in Group C did not affect immunogenicity. Progesterone was suppressed significantly in comparison to controls. Future studies that monitor fertility through multiple breeding cycles represent a research need to determine the value of integrating this vaccine into dog rabies management. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
机译：墨西哥是犬狂犬病预防和控制的全球典范。墨西哥卫生部（MMH）每年应用约1600万剂肠胃外狂犬病疫苗，在过去20年中导致犬狂犬病显着减少。狂犬病项目的一个附带参数是狗的数量管理。增强公众意识对于加强负责任的宠物所有权至关重要。手术切除和绝育对防止繁殖仍然很重要，但对于实现犬只种群管理目标来说是不切实际的。 GonaCon（TM）是一种抗促性腺激素释放激素（GnRH）疫苗，最初于2008年在纳瓦霍国家（Navajo Nation）的圈养雌性犬中进行了测试。 2011年在墨西哥伊达尔戈的当地代表。该研究包含20个母犬，分别分配给A组（6个对照组），B组（7个GonaCon（TM））和C组（7个GonaCon（TM）和狂犬病疫苗）。疫苗是IM即时交付的。将动物置于观察下并在61天的试验过程中进行评估。临床上，所有狗的行为都正常。尽管接受GonaCon（TM）的狗的左后肢有轻微肌肉萎缩，但未观察到行或虚脱。两只开始怀孕研究的狗生下了健康的幼崽。接受了GonaCon（TM）注射的狗的宏观和微观损伤与先前的发现一致，但是不良注射作用的频率较低且强度较低。两种疫苗都是基于治疗组B和C中狂犬病毒中和抗体和抗GnRH抗体的显着增加而产生的免疫原性。在组C中同时施用GonaCon（TM）和狂犬病疫苗不会影响免疫原性。与对照相比，孕酮被显着抑制。未来通过多个繁殖周期监测生育力的研究表明，需要确定将这种疫苗整合到犬狂犬病管理中的价值的研究。 （C）2013作者。由Elsevier Ltd.出版。保留所有权利。

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