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首页> 外文期刊>Vaccine >The B-cell response to a primary and booster course of MenACWY-CRM197 vaccine administered at 2, 4 and 12 months of age
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The B-cell response to a primary and booster course of MenACWY-CRM197 vaccine administered at 2, 4 and 12 months of age

机译：B细胞对在2、4和12个月大时服用MenACWY-CRM197疫苗的初次和加强疗程的反应

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A quadrivalent meningococcal vaccine conjugated to CRM197 (MenACWY-CRM197) is immunogenic in young infants. We assessed the memory B-cell and antibody responses after a primary and booster course of MenACWY-CRM197 in children. At 5 months of age, following primary immunisation, serogroup-specific memory B-cells were detectable in fewer than 25% of children, although protective antibody titres (hSBA >= 4) were detectable in 69% of children against serogroup A and more than 95% against the other serogroups. At 12 months, before booster immunisation the percentages with hSBA >= 4 were 5% for serogroup A, and between 44 and 70% for the other serogroups. One month after booster immunisation with MenACWY-CRM197 over 50% of children had detectable memory B-cells, and 91% had hSBA >= 4 against serogroup A and more than 99% against the other serogroups. These data show that few antigen-specific anticapsular memory B-cells can be detected after two-doses priming with MenACWY-CRM197. For MenC and CRM197, the antigens with the highest number of B-cells at 5 months, there was a definite (p <= 0.02) but weak correlation with antibody persistence at 12 months. Although previous studies suggest that measuring memory B-cell responses after priming immunisations in infancy can be used to predict antibody persistence and memory responses, this may not be suitable for all antigens in young children
机译：与CRM197偶联的四价脑膜炎球菌疫苗（MenACWY-CRM197）在婴儿中具有免疫原性。我们评估了儿童MenACWY-CRM197的初次和加强过程后的记忆B细胞和抗体反应。初次免疫后，在5个月大时，不到25％的儿童可检测到血清群特异性记忆B细胞，尽管69％的儿童针对血清群A可检测到保护性抗体滴度（hSBA> = 4），且针对其他血清群的95％。在加强免疫前的12个月，血清群A的hSBA> = 4的百分比为5％，其他血清群的hSBA> = 4的百分比为44％至70％。用MenACWY-CRM197加强免疫后一个月，超过50％的儿童可检测到记忆B细胞，而91％的hSBA> = 4针对血清群A，超过99％的针对其他血清群。这些数据表明，用MenACWY-CRM197进行两剂启动后，几乎没有抗原特异性抗荚膜记忆B细胞能被检测到。对于MenC和CRM197，在5个月时B细胞数量最多的抗原在12个月时具有确定的（p <= 0.02）但与抗体持久性的相关性较弱。尽管以前的研究表明在婴儿期初次免疫后测量记忆B细胞反应可用于预测抗体的持久性和记忆反应，但这可能并不适合于幼儿中的所有抗原

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