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Effectiveness of the 2010-11 seasonal trivalent influenza vaccine in Spain: cycEVA study

机译：cycEVA研究表明2010-11年西班牙季节性三价流感疫苗的有效性

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Background: In Spain, the influenza vaccine effectiveness (VE) was estimated in the last three seasons using an observational study (cycEVA) conducted in the frame of the Spanish Influenza Sentinel Surveillance System. We aimed to measure the effectiveness of the seasonal trivalent vaccine in preventing influenza like illness (ILI) laboratory-confirmed influenza infection at the end of the season 2010-11. Methods: We conducted a test-negative case-control study between weeks 50/2010 and 12/2011. Cases were ILI laboratory-confirmed influenza infection and controls were those testing negative. Sentinel physicians collected data on demographic and clinical characteristics, vaccination status, and on covariates related to confounding factors associating with influenza VE. We calculated adjusted odds ratios (OR), using logistic regression and computed influenza VE as (1 - OR) x 100. Results: The adjusted influenza VE against A(H1N1)pdm09 infection was 46% (95% confidence interval (95%CI): 0; 72). In A(H1N1)pdm09 infected patients who had received both 2010-11 trivalent influenza seasonal and 2009 monovalent pandemic vaccines, influenza VE was 74% (95%CI: 13; 93). The adjusted influenza VE against B infection was 23% (95%CI: 180; 79). Conclusion: The trivalent influenza vaccine 2010-11 showed a moderate VE for preventing ILI laboratory confirmed influenza infections. Influenza VE estimates were higher in patients who had received both 2010-11 seasonal trivalent and 2009 monovalent pandemic vaccines. (C) 2012 Elsevier Ltd. All rights reserved.
机译：背景：在西班牙，使用在西班牙流感前哨监视系统框架内进行的观察性研究（cycEVA）估算了过去三个季节中的流感疫苗效力（VE）。我们的目标是在2010-11赛季末评估季节性三价疫苗在预防流感样疾病（ILI）实验室确认的流感感染中的有效性。方法：我们在50/2010周至12/2011周之间进行了测试阴性病例对照研究。病例为ILI经实验室确认的流感感染，对照为阴性。前哨医师收集了有关人口统计学和临床​​特征，疫苗接种状况以及与与流感VE相关的混杂因素相关的协变量的数据。我们使用logistic回归计算调整后的优势比（OR），并将流感病毒VE计算为（1-OR）x100。结果：针对A（H1N1）pdm09感染的调整后流感病毒为46％（95％置信区间（95％CI） ）：0; 72）。在同时接种了2010-11年三价季节性流感疫苗和2009年一价大流行疫苗的A（H1N1）pdm09感染患者中，流感VE为74％（95％CI：13; 93）。调整后的针对B感染的流感VE为23％（95％CI：180; 79）。结论：2010-11年三价流感疫苗显示中等程度的VE，可预防ILI实验室确认的流感感染。接受了2010-11年度季节性三价和2009年单价大流行疫苗接种的患者，其VE估计较高。 （C）2012 Elsevier Ltd.保留所有权利。

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